Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation: not irritating

Eye irritation: not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
July 10, 2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The model is been assessed according to the OECD principles for the validation of QSAR, to generate a transparent, understandable, reproducible and verifiable result.
Qualifier:
according to guideline
Guideline:
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
Prediction was calculated using QSAR Toolbox v.4.4.1
Data gap filling method: Read-across analysis
Remarks on result:
no indication of irritation
Remarks:
According to the (Q)SAR Toolbox results
Interpretation of results:
GHS criteria not met
Conclusions:
Diisopropyl maleate is not predicted to exhibit skin irritation by QSAR Toolbox, evaluating experimental existing data on similar substances.
Executive summary:

Diisopropyl maleate is not predicted to exhibit skin irritation by QSAR Toolbox, evaluating experimental existing data on similar substances.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
July 10, 2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The model is been assessed according to the OECD principles for the validation of QSAR, to generate a transparent, understandable, reproducible and verifiable result.
Qualifier:
according to guideline
Guideline:
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
Prediction was calculated using QSAR Toolbox v.4.4.1
Data gap filling method: Read-across analysis
Remarks on result:
no indication of irritation
Remarks:
According to the (Q)SAR Toolbox results
Interpretation of results:
GHS criteria not met
Conclusions:
Diisopropyl maleate is not predicted to exhibit eye irritation by (Q)SAR Toolbox, evaluating experimental existing data on similar substances.
Executive summary:

Diisopropyl maleate is not predicted to exhibit eye irritation by (Q)SAR Toolbox, evaluating experimental existing data on similar substances.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Results based on (Q)SAR Toolbox model assessed according to the OECD principles for the validation of QSAR.