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EC number: 219-440-1 | CAS number: 2437-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from robust summary.
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Version / remarks:
- No data available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Determination of short term toxicity and Acute Immobilization Test of Dodecanenitrile to Daphnia magna.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: Dodecanenitrile
- Molecular formula: C12H23N
- Molecular weight: 181.321 g/mole
- Smiles notation: C(CCCCCC)CCCCC#N
- InChl: 1S/C12H23N/c1-2-3-4-5-6-7-8-9-10-11-12-13/h2-11H2,1H3
- Substance type: organic
- Physical state: colourless liquid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- No data available
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- No data available
- pH:
- No data available
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Conductivity:
- No data available
- Nominal and measured concentrations:
- No data available
- Details on test conditions:
- No data available
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Immobility was observed
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the immobilization of daphnia due to the exposure with chemical Dodecanenitrile, the LC50 was 0.33 mg/l for 48hrs.
- Executive summary:
Determination of short term toxicity and Acute Immobilization Test of Dodecanenitrile to Daphnia species. Study was performed in static system for 48hrs exposure of chemical Dodecanenitrile to daphnia.
Based on the immobilization of daphnia due to the exposure with chemical Dodecanenitrile, the LC50 was 0.33 mg/l for 48hrs. Thus chemical Dodecanenitrile was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
Reference
Description of key information
Determination of short term toxicity and Acute Immobilization Test of Dodecanenitrile to Daphnia magna. Test was performed according to the OECD guidelines in the semi-static system for 48hrs.
For the study dechlorinated water were used. Various concentrations was prepared 0.73, 0.36, 0.16, 0.078, 0.035 mg/L as measured concentration, one control was also used. The test solution prepared by adding test substance and test water were mixed to give 100 mg/L (nominal), and stirred for about 48 hours. Some amount of solution in middle layer was extracted for stock solution to prepare test solutions by mixing and stirring with test water.
Based on the immobilization of daphnia magna due to the exposure with chemical Dodecanenitrile, the EC50 was 0.059 mg/l for 48hrs. thus chemical Dodecanenitrile was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.059 mg/L
Additional information
Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of Dodecanenitrile (2437-25-4) on the growth of fishes. The studies are as mentioned below:
In the first experimental key study for Dodecanenitrile (2437-25-4) from j-check, 2017 Determination of short term toxicity and Acute Immobilization Test of Dodecanenitrile to Daphnia magna. Test was performed according to the OECD guidelines in the semi-static system for 48hrs. For the study dechlorinated water were used. Various concentrations was prepared 0.73, 0.36, 0.16, 0.078, 0.035 mg/L as measured concentration, one control was also used. The test solution prepared by adding test substance and test water were mixed to give 100 mg/L (nominal), and stirred for about 48 hours. Some amount of solution in middle layer was extracted for stock solution to prepare test solutions by mixing and stirring with test water. Based on the immobilization of daphnia magna due to the exposure with chemical Dodecanenitrile, the EC50 was 0.059 mg/l for 48hrs. thus chemical Dodecanenitrile was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
Similarly in the second supporting study for Dodecanenitrile (2437-25-4) episuite, 2017, toxicity was measured. Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 0.358 mg/l for Dodecanenitrile in 48 hrs. Based on this value it can be concluded that the substance Dodecanenitrile is considered to be toxic to aquatic environment and can be classified in aquatic acute 1 category as per the criteria mentioned in CLP regulation.
Similarly in the third supporting study for Dodecanenitrile (2437-25-4) 2003, toxicity was measured. Determination of short term toxicity and Acute Immobilization Test of Dodecanenitrile to Daphnia species. Study was performed in static system for 48hrs exposure of chemical Dodecanenitrile to daphnia. Based on the immobilization of daphnia due to the exposure with chemical Dodecanenitrile, the LC50 was 0.33 mg/l for 48hrs. Thus chemical Dodecanenitrile was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
Similarly in the fourth supporting study for RA chemical 1-Octanethiol (111-88-6), j-check, Determination of short term toxicity of 1-Octanethiol on the mobility of daphnia was studied by providing the exposure of chemical for 48hrs. Test was performed by following the standard OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). After the 48hrs of exposure interval period, toxicity and immobilisation was observed. Based on the inhibition of mobility of daphnia species due to the exposure of chemical 1-Octanethiol, the EC50 was 0.024 mg/l. Thus based on the EC50, chemical 1-Octanethiol was consider as toxic and can be consider to be classified as aquatic acute 1 category as per the CLP classification criteria.
In the same manner by considering fifth supporting study for the RA chemical 1-Hexanethiol (111 -31 -9), from ecotox databases 2017, Evaluation of short term toxicity of 1-Hexanethiol studied on the growth of daphnia magna by providing the exposure period of 24hrs. Test performed in static system. After the exposure effect concentration was observed on the basis of behavioral changes in daphnia magna and measure effect by the equilibrium. Based on the behavior of daphnia magna after the exposure of chemical 1-Hexanethiol for 24hrs, the EC50 was 0.073 mg/l. Thus chemical 1-Hexanethiol was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
Based on the data obtain from various experimental studies for the immobility due to the exposure of Dodecanenitrile thus it was concluded that the chemical Dodecanenitrile was consider as toxic and can be consider to be classified as aquatic acute 1 category as per CLP classification criteria.
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