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EC number: 606-630-8 | CAS number: 20765-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11-14 March 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP. It should be noted that this record was produced using an English translation of the study report that was written in German.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Rhodium (III) chloride hydrate
- IUPAC Name:
- Rhodium (III) chloride hydrate
- Reference substance name:
- 20765-98-4, 13465-43-5
- IUPAC Name:
- 20765-98-4, 13465-43-5
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Rhodium (III) chloride hydrate
- Substance type: No data
- Physical state: Dark red crystals
- Analytical purity: 99.5% (38.3% Rh)
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: Ir, 0.005%; Ag, 0.002%; Cu 0.001%; Ca, 0.005%; Mg, 0.002%; Si, 0.003%
- Isomers composition: Not applicable
- Purity test date: 18 February 1986
- Lot/batch No.: 27461
- Expiration date of the lot/batch: No data
- Stability under test conditions: According to information of the sponsor, the test substance was stable throughout the experimental period
- Storage condition of test material: Room temperature
- Other: Soluble in water and ethanol
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: White russian (albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 6-7 Months
- Weight at study initiation: 2.2-2.5 kg
- Housing: Individually housed in ASTA Model stainless steel cages
- Diet (e.g. ad libitum): Standard diet ad libitum (ssniff K “special diet for rabbits” supplied by ssniff Spezialfutter GmbH, D-4770 Soest)
- Water (e.g. ad libitum): Water was provided ad libitum in drinking water quality of the Stadtwerke Bielefeld
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1
- Humidity (%): 55 ± 10
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): Not applicable
VEHICLE
- Amount(s) applied (volume or weight with unit): Moistened with 0.4 mL water
- Concentration (if solution): Not applicable
- Lot/batch no. (if required): Not applicable
- Purity: Not applicable - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days (observations at 1, 24, 48 and 72 hrs after removal of the patch)
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: Test item was applied to shaved skin on the back of the rabbit, between the shoulder blade and the sacrum.
- % coverage: No data
- Type of wrap if used: The site of application was covered with approx 6.25 cm2 of a linen cloth which adhered to a synthetic film glue. A bandage (Acrylastic, No. 2408, width 8 cm) was wrapped several times around the trunk to provide a complete occlusion.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: Not applicable
SCORING SYSTEM: Erythema (and eschar) formation and oedema formation were assessed qualitatively and quantitatively on the skin of 3 rabbits using the Draize method, 1, 24, 48 and 72 hr after removal of the patch. The cutaneous irritation index at the four time points was determined separately for erythema (and eschar) formation and oedema formation, based on the arithmetical mean values of the individual grades. The irritation index was graded in a modified method according to Gilman et al:
Irritation index Evaluation
0.0-0.5 non-irritant
0.6-3.0 slightly irritant
3.1-5.0 moderately irritant
5.1-8.0 severely irritant
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hours post application
- Score:
- ca. 0
- Max. score:
- 8
- Reversibility:
- other: Not applicable
- Remarks on result:
- other: No signs of irritation were apparent in any animal during the observation period
- Irritant / corrosive response data:
- There were no signs of irritation observed during the observation period
- Other effects:
- No systemic toxic effects were seen in the animals after application of the test material and the general condition of the animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a guideline study, to GLP, no irritation potential was observed when rhodium (III) chloride hydrate was applied (under occlusion for 4 hr) to the shaved, intact skin of three male rabbits.
- Executive summary:
In an OECD Test Guideline 404 study, conducted according to GLP, rhodium (III) chloride hydrate (0.5 g, moistened) was applied (occluded) to the shaved, intact skin of three male White Russian rabbits. After 4 hr, the dressings were removed and the skin sites quantitatively and qualitatively assessed for signs of irritation (oedema and erythema/eschar) and corrosion at 1, 24, 48 and 72 hr.
No irritation (erythema/eschar formation or erythema) or corrosion of the skin was seen at any time point during the 72 hr observation period. The primary irrational index was therefore 0, andrhodium (III) chloride hydratewas therefore considered non-irritant in this test. There was no evidence of systemic toxic effects after application of the test material and no deleterious effects to the general condition of the animals.
No skin classification, according to EU CLP criteria (EC 1272/2008), is required on the basis of this study.
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