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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Jul - 11 Jul 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Testing Methods for New Chemical Substances
- Version / remarks:
- March 31, 2011, No.0331-7, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare; March 29, 2011, No.5, Manufacturing Industries Bureau, Ministry of Economy, Trade and Industry; No. 110331009, Environmental Policy Bureau, Ministry of the Environment, Japan.) VI. Fish acute toxicity test
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- Adopted: 17 July 1992
- GLP compliance:
- yes
Test material
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 100 mg/L
- Sampling method: Test solutions for measurement were taken from mid-depth of the test vessel of each test group without agitation (n = 1).
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 0.5917 g of the test substance was weighed with the electronic balance. A stock solution was prepared by mixing the test substance with the dilution water to a volume of 100 mL and then stirred for 48 h with a magnetic stirrer at 23 ± 1 °C. The test solution of 100 mg/L was prepared by diluting the whole volume of the stock solution with the dilution water to make 5 L.
- Eluate: no
- Differential loading: no
- Controls: yes, test medium control
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: medaka
- Strain: Oryzias latipes
- Source: in-house culture
- Length at study initiation: 21 - 26 mm; Mean: 25 mm (n = 20)
- Weight at study termination: 0.06 - 0.16 g; Mean: 0.12 g (n = 20)
ACCLIMATION
- Acclimation period: ≥ 12 d
- Acclimation conditions: same as test with recirculatory filtering system
- Type and amount of food during acclimation: commercial feed, 5 % of body weight
- Feeding frequency during acclimation: 5 times a week
- Health during acclimation: 0 % mortality
FEEDING DURING TEST
- Frequency: no feeding
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 43 mg CaCO3/L at the initiation of exposure
- Test temperature:
- 23.0 - 23.3 °C
- pH:
- 7.8 - 8.2
- Dissolved oxygen:
- 6.4 - 8.1 mg/L, maintained at ≥ 60% of the air saturation value in all test groups
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
mean measured: control, 101 mg/L - Details on test conditions:
- TEST SYSTEM
- Type: covered with a lid
- Material, size, headspace, Material: glass; inside size ca. 21 cm D x 16 cm W x 23 cm H; headspace: 0 L; fill volume: 5 L
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water (Takarazuka-shi, Hyogo) dechlorinated with charcoal filter
- Total organic carbon: 0.6 mg/L
- Metals: most < LOD except: Fluoride: 0.2 mg/L; Sulfate ion: 34 mg/L
- Pesticides: < LOD
- Chlorine: < LOD
- Alkalinity: 50 mg/L
- Ca/mg ratio: 14 mg/L Ca, 3.1 mg/L Mg
- Intervals of water quality measurement: at initiation and termination of exposure
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/8 h dark
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable, limit test
- Range finding study: yes
- Test concentrations range finding study: control, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: yes; 0 % mortality at 100 mg/L in the range-finding test - Reference substance (positive control):
- yes
- Remarks:
- Copper [cupric] sulfate pentahydrate (tested twice a year)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0 %
- Abnormal responses: no abnormal response was recorded. All fish behaved normally. - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- LC50 (96 h): 0.45 mg/L
- historical LC50 (96 h): 2.4 ± 1.6 mg/L (mean ± S.D., n = 25)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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