Reaction mass of decyl acrylate and octyl acrylate

Endpoint summary

Description of key information

No experimental toxicokinetic study is available on Reaction mass of decyl and octyl acrylate.

However, as per REACH guidance document R7.C (2012), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.

Based on the toxicological data and the physicochemical properties, the absorption of Reaction mass of decyl and octyl acrylate is expected to be low by oral, dermal and inhalation exposure.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

10

Absorption rate - inhalation (%):

100

Additional information

No experimental toxicokinetic study is available on Reaction mass of decyl and octyl acrylate.

However, as per REACH guidance document R7.C (2012), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

-Mean molecular weight: [184.28 -212.34] g/mol

-Water solubility: 4.11 mg/L (20°C)

-Partition coefficient Log Kow: [4,82 -5.89]

-Vapour pressure: 22.7 Pa (25°C)

 

ABSORPTION

The high value of log Kow (>4) and the low solubility (<100 mg/L) of Reaction mass of decyl and octyl acrylate are favorable for a low oral absorption. Indeed, no clinical effects or mortality were observed after one single administration (5000 mg/kg) of Reaction mass of decyl and octyl acrylate by gavage (oral route) in rat. An oral absorption is expected to be low for Reaction mass of decyl and octyl acrylate, however 100% of absorption is taken into account for the risk assessment (worst case).

With a solubility of 4.11 mg/L, dermal absorption is anticipated to be low to moderate. A Log Kow higher close to 4 suggests that the rate of penetration of the substance may be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of Reaction mass of decyl and octyl acrylate is anticipated to be low. Indeed, no mortality was observed in the acute study by dermal route in rabbits (4400 mg/kg bw). However, Reaction mass of decyl and octyl acrylate is considered to be skin sensitizing based on the experimental data available on octyl acrylate (positive GPMT). That's why 10% of absorption is taken into account for the risk assessment for Reaction mass of decyl and octyl acrylate (worst case).

Based on the vapour pressure value (22.7 Pa), Reaction mass of decyl and octyl acrylate is considered to be not a volatile substance because lower than 100 Pa. Indeed, the absorption by inhalation can be expected to be low for Reaction mass of decyl and octyl acrylate based on the values of water solubility and log kow. However 100% of absorption is taken into account for the risk assessment (worst case).

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of Reaction mass of decyl and octyl acrylate. No adverse effect or target organ toxicity were observed in the 28 -day repeated toxicity study performed on C12 -C14 acrylate.

 

ELIMINATION

Due to the low water solubility, the excretion of Reaction mass of decyl and octyl acrylate in the urines is expected to be low. An excretion via bile and faeces is possible.