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Diss Factsheets
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EC number: 211-112-6 | CAS number: 629-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The aqua tox data indicate that the toxicity in all tests is above the water solublity of the test item in the respective media. Therefore, no hazards are identified.
Additional information
For each of three trophic levels, one reliable and relevant acute toxicity study is available.
The acute toxicity to fish was determined to be LC50 = 3200 mg/l.
The acute toxicity to Daphnia was determined to be EC50 >100 mg/L.
The acute toxicity to algae was determined to be EC50 (growth rate) = 26.16 mg/L, with a NOEC of 12.5 mg/L.
The acute toxicity to Lemna was determined to be NOEC: 0.942 mg/L , the range of the functional water (media) solubility.
One reliable and relevant chronic toxicity study is available. In a Daphnia reproduction test a NOEC of 12.5 mg/L was determined.
Verification test with Lemna:
In order to overcome potential shortcomings with the analytical monitoring of the test concentrations, it was decided to repeat the algae test OECD 201 with a special focus on recovery rates of the test item in the exposure vessels to verify the previous finding in the acute tests.
In sum 6 different pretest were performed in order to verify the intended exposure concentrations in the range of close to 2 µg/L which corresponds to the functional water solubility in the algae media.
Despite of all reasonable efforts, it was not possible to keep the intended concentration in the exposure vessels under static conditions over the exposure period of 72 hours.
However, predict effects on plant organisms, it seemed more promising to switch to a semi-static testing regime (OECD 221) with Lemna (Lemna gibba) with a daily water exchange of the test medium and a close analytical monitoring of the intended test concentration.
A nominal concentration of 6 µg/L turned out to be a realistic concentration to reach a saturated media concentration of 0.942 µg/L (mean measured). With a NOEC of 0.942 µg/L and an EC10, EC50 > 0.942 µg/L with regard to growth inhibition (frond number and dry weight) as well as to yield inhibition, not effects were observed for Lemna within the range of media solubility.
Conclusion:
The water solubility of the test item in test media is very low. In Lemna media it is in the range of 0.942 µg/L. Based on the Leman test result it can be concluded that in the range of the water solubility, the test item is not toxic to water organisms and therefore is considered to confirm the previous results in algae, daphnia and fish: no toxicity within the range of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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