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EC number: 931-275-3 | CAS number: 1125503-33-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral median lethal dose (LD50) of Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS), to the Sprague-Dawley strain rat was found to be greater than 200 mg/kg body weight but less than 2000 mg/kg bodyweight (nominal concentration). The study was performed with a 35% (w/v) solution in water according to OECD 401. In a second study (up and down method according to OECD 425) with an analogue quaternary ammonium compound (C13-15 dimethyl hydroxyethylammonium chloride) which is similar in structure (for Read across justification refer to IUCLID section 13, Assessment reports), the LD50 was determined to be 1300 mg/kg bw (nominal concentration). The active ingredient /purity of this substance were approx. 30 % (w/v) solution in water.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Additional information
The acute oral median lethal dose LD 50 (acute oral toxicity) of Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) to the Sprague-Dawley strain rat was determined to be greater than 200 mg/kg body weight but less than 2000 mg/kg bodyweight (nominal concentration). It was performed in an OECD 401 study with a 35% (w/v) solution in water. In a second independent trial (up and down method acc. to OECD 425) the LD 50 was determined to be 1300 mg/kg bw (nominal concentration). This study was performed with a similar quaternary ammonium compound of approx. 30 % (w/v) solution in water (For Read-across justification refer to IUCLID section 13, Assessment reports).
In accordance with column 2 of Reach Regulation (EC) No 1907/2006 Annex VIII the acute dermal toxicity study and the acute inhalation toxicity study (required in section 8.5) does not need to be conducted as the test substance is corrosive to the skin. Furthermore, inhalation is no endpoint of concern since inhalation is no critical route of exposure and no peak exposures are to be expected.
Justification for classification or non-classification
Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) has to be classified with regard to acute oral toxicity as "Xn, R22, harmful if swallowed" according to DSD (Dangerous Substance Directive). According to Regulation (EC) No 1272/2008 of the European Parliament and of the Council,16 December 2008 (CLP or GHS (Global harmonized System for classification, labeling and packaging) an LD50 cut-off value of 1000 mg/kg bw is established. Based hereupon HYEQS has to be classified with regard to acute oral toxicity in "Cat 4 oral (>300 – 2000)". This cut-off value of 1000 mg/kg is revealed when using the individual data from the OECD 401 study and applying the evaluation scheme in Annex 2d of the OECD test guideline 423. No classification for acute dermal and acute inhalation toxicity is deducible.
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