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EC number: 204-582-9 | CAS number: 122-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral
The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt.
Acute toxicity: dermal
The acute dermal LD50 of test compound Anisyl formate in rabbit was found to be more than 5000mg/kg b.wt. (> 5000 mg/kg b.wt.).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: (4-methoxyphenyl)methyl formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 150 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed.
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Category 4 based on CLP criteria
- Conclusions:
- The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route. 50% mortality was observed at 1150.0 mg/kg b.wt in treated rats. The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt. Thus, by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Anisyl formate (CAS No. 122 -91-8) can be classify under category 4 compound at the tested dose levels.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 150 mg/kg bw
- Quality of whole database:
- The data is K2 level and from a peer-reviwed journal.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- Data is from peer-reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rabbit by the dermal route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: (4-methoxyphenyl)methyl formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid - Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed.
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified based on CLP criteria
- Conclusions:
- The acute dermal LD50 of test compound Anisyl formate in rabbit was found to be more than 5000mg/kg b.wt. (> 5000 mg/kg b.wt.).
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rabbit by the dermal route. The acute dermal LD50 of test compound Anisyl formate was found to be more than 5000mg/kg b.wt. (> 5000 mg/kg b.wt.). Thus, according to CLP criteria for acute toxicity rating for the chemicals, the test compound Anisyl formate (CAS No. -122-91-8) can be classify under non toxic category at the tested dose level of 5000 mg/kg body weight.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The data is K2 level and from a peer-reviwed journal.
Additional information
Acute toxicity: oral
In different studies, anisyl formate (CAS No.122-91-8) has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for anisyl formate along with the study available on structurally similar read across substance anisaldehyde/p-methoxybenzaldehyde (CAS No. 123-11-5) and vanillin (CAS No. 121-33-5). The predicted data using the OECD QSAR toolbox has also been compared with the experimental data. The studies are summarized as below:
The acute toxicity study published in a peer-reviewed journal (Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Page 685); in which the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route was examined. 50% mortality was observed at 1150.0 mg/kg b.wt in treated rats. The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt.
The above acute oral toxicity study is supported by another experimental study given by Levenstein, I. (1975); in which the study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route. 50% mortality was observed at 1800.0 mg/kg b.wt in treated rats.The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1800.0 mg/kg b.wt.
Also the acute toxicity study was predicted using OECD QSAR toolbox version 3.3 (2017); to evaluate the toxic effects of administration of anisyl formate (CAS No. 122-91-8) in rat by the oral route. 50% mortality was observed. Thus, the acute oral median lethal dose (LD50) of Anisyl formate in rat was estimated to be 858.28 mg/kg b.wt.
This is further supported by the study published in a peer reviewed journal (P. M. Jenner, e. C. Hagan, jean m. Taylor, e. L. Cook and o. G. Fitzhugh,Food Flavourings and Compounds of Related Structure I. Acute Oral Toxicity, Fd Cosmet. Toxicol. Vol. 2, pp. 327-343, 1964.); in which the acute toxicity study was conducted to evaluate the toxic effects of administration of anisaldehyde/p-methoxybenzaldehyde (CAS No. 123-11-5) in rat by the oral route. Groups of 10 young adult Osborne-Mendel rats evenly divided by sex were fasted for approximately 18 hr prior to treatment. Oral dosage of anisaldehyde was administered by intubation to the rats. Animals were observed usually for 2 weeks during which time the development of toxic signs was followed and time of death recorded. The acute oral LD50 was determined. Depression was observed and death time was recorded as 4-18 hours. The acute oral median lethal dose (LD50) of anisaldehyde in rat was observed to be 1510.0 mg/kg b.wt with 95% confidence limit of 1360.0 – 1700.0 mg/kg.
Moreover in a study by Jean m. Taylor et. al (Toxicology and applied pharmacology 6, 378-387,1964), the acute oral toxicity of vanillin was determined in rats of the Osborne-Mendel or Sherman strain. The compound was administered by stomach tube to rats fasted 18 hours. A group of five males and five female rats were used. The rats were observed until the survivors had returned to normal in appearance and weight during which time the development of toxic signs was followed and time of death recorded. Comatose soon after treatment, scrawny appearance for several days and death time was recorded as 4 hours to 4 days. The acute oral median lethal dose (LD50) of vanillin in rat was observed to be 1580.0 mg/kg b.wt with 95% confidence limit of 1390.0 – 1810.0 mg/kg.
So, based on the above mentioned studies for target substance Anisyl formate (CAS No. 122-91-8) and to its read across substance, the median lethal dose (LD50) value was found to be in the range of 858.28 mg/kg bw to 1800.0 mg/kg b.wt. Thus, by comparing these studies with the criteria of CLP regulation, it infers that anisyl formate (CAS No. 122-91-8) can be classify under category 4 compound at the tested dose levels.
Acute toxicity: dermal
A study published in a peer-reviewed journal (Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Page 685.); in which the acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rabbit by the dermal route. The acute dermal LD50 of test compound Anisyl formate was found to be more than 5000mg/kg b.wt. (> 5000 mg/kg b.wt.). Thus, according to CLP criteria for acute toxicity rating for the chemicals, the test compound Anisyl formate (CAS No. -122-91-8) can be classify under non toxic category at the tested dose level of 5000 mg/kg body weight.
Justification for classification or non-classification
Based on the above mentioned studies on Anisyl formate (CAS No. – 122-91-8), it can be found that LD50 oral value is in the range of 300 to ≤2000 mg/kg b.wt and LD50 dermal value is >2000 mg/kg b.wt. Thus, by comparing these studies with the criteria of CLP regulation, it infers that the test substance anisyl formate (CAS No. -122-91-8) can be classify as an acute oral toxicant in category 4 whereas anisyl formate does not classify as an acute toxicant by the dermal route.
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