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Diss Factsheets
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EC number: 232-245-6 | CAS number: 7791-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given, peer reviewed, study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat.
- Author:
- Albert RE et al.
- Year:
- 1 982
- Bibliographic source:
- J Natl Cancer Inst 68, 579-604
- Reference Type:
- publication
- Title:
- Carcinogenicity of formaldehyde and hydrogen chloride in rats.
- Author:
- Sellakumar AR et al.
- Year:
- 1 985
- Bibliographic source:
- Toxicol Appl Pharmacol 81, 401-406 cited in OECD SIDS Sulfuryl chloride
- Reference Type:
- secondary source
- Title:
- Hydrogen chloride (CASRN 7647-01-0)
- Author:
- US EPA
- Year:
- 1 995
- Bibliographic source:
- Integrated Risk Information System. US Environmental Protection Agency (http://www.epa.gov/iris/subst/0396.htm)
- Reference Type:
- secondary source
- Title:
- Sulfuryl chloride, CAS No.:7791-25-5, SIAR
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP publications
Materials and methods
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- IUPAC Name:
- chloride
- Details on test material:
- Test substance: hydrogen chloride
Purity: 99.0% grade (Matheson Gas Products, East Rutherford, N.J.)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Details on exposure:
- overall gas mixture flow rate of 4 liters/minute
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- lifetime
- Frequency of treatment:
- 6 hours/day and 5 days/week during lifetime
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 0.015 mg/L (10 ppm)
Basis:
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- 29 % mortality after 588 days (control: 28 %).
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- 29 % mortality after 588 days (control: 28 %).
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- No significant change when compared with controls.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Complete necropsy was performed on all animals, with particular attention given to the respiratory tract. Histological sections were prepared from the nasal cavity (one lateral section from each side of the head), lung (one section from each lobe), trac
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Totally, 19 and 25 tumours were found in treated and control rats, respectively. Type and incidence of tumours were not significantly different. No nasal tumours were observed in both treated and control animals.
- Details on results:
- Result (carcinogenicity): negative
Any other information on results incl. tables
The Albert et al. (1982) study, discussed in detail by
Sellakumar et al. (1985), reported data from a chronic
inhalation exposure study in rats. One hundred male
Sprague-Dawley rats were exposed to 10 ppm hydrogen chloride
(HCl) for 6 hours/day, 5 days/week (duration-adjusted
concentration = 2.5 mg/m3) for their lifetimes. All animals
were observed daily, weighed monthly, and allowed to die
naturally or killed when moribund. Complete necropsy was
performed on all animals, with particular attention given to
the respiratory tract. Histological sections were prepared
from the nasal cavity (one lateral section from each side of
the head), lung (one section from each lobe), trachea,
larynx, liver, kidneys, testes, and other organs where gross
pathological signs were present. However, Sellakumar et al.
(1985) did not discuss histopathological events in organs
other than the respiratory tract. HCl-exposed animals showed
no differences in body weights or survival when compared
with air controls. The data indicated 62/99 exposed animals
with epithelial or squamous hyperplasia in the nasal mucosa
(location not specified) vs. 51/99 in the concurrent control
group. Incidence of squamous metaplasia was 9 and 5 in the
exposed and control rats, respectively. There was a 24 %
incidence of hyperplasia of laryngeal-tracheal segments in
HCl-exposed rats (larynx 2/22, trachea 6/26) vs. 6 % in the
controls. The authors did not make any comments concerning
the severity of these changes. Based on these results, the
US EPA (1995) gave 10 ppm as LOAEL [LOAEL(HEC) = 6.1 mg/m3).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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