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Diss Factsheets
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EC number: 244-966-3 | CAS number: 22412-97-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. The analytical purity of the substance in the test product was not reported. Instead, it was based upon the estimated ranges for the product derived from the production recipe.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- the analytical purity of the test substance is not reported
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- 30 young albino rats, equal number of male and female rats
- Weight at study initiation: 200-300 g
- Fasting before study: yes, 24 h
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no information - Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30%
- Amount of vehicle + substance: 2, 4, 6, 16, 20, 25, 32, 64 mL/kg - Doses:
- 0.7, 1.3, 2.0, 5.3, 6.7, 8.3, 10.7, 21 g/kg bw
- No. of animals per sex per dose:
- 5 animals per dose, male or female, both sexes were equally distributed..
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- After dosage animals on the same dosage level were placed in a common cage with free access to food and water.
- The animals were observed daily for a two week period.
- No postmortem, or histopathology examinations were performed in this particular study. - Statistics:
- LD50 calculation based on probit analysis.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 7 670 - <= 9 600
- Mortality:
- Total dose Test material Animals Animals
exposed dead % mortality
20 6.7 5 0 0
25 8.3 5 2 40%
32 10.7 5 5 100%
64 21.3 5 5 100% - Clinical signs:
- The animals dosed at 0.7-1.3 g/Kg: unkempt coats for 12-16 hours after dosing. At 2.7 g/Kg: sluggish and impaired locomotion and unkempt coats whch recovered within 48 hours. At 5.3 and 6.7 g/kg: Staggering gait and impaired locomotion accompanied with ruffled and unkempt coats. At higher doses: Loss of motor control and dirty unkempt coats were evident, coma prior to death.
- Body weight:
- No information available.
- Gross pathology:
- No information available.
- Other findings:
- No information available.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 600 mg/kg bw
- Quality of whole database:
- Klimisch code 2, pre-GLP studies with basic data on methods and results.
Additional information
The key study performed with a product containing both tetradecyl laurate and tetradecyl myristate resulted in an LD50 of 8.6 g/kg bw (8600 mg/kg bw). No mortality occurred at 6700 mg/kg bw. A supporting study with tetradecyl myristate confirmed that the LC50 is > 5000 mg/kg bw. Hence, tetradecyl laurate does not require classification or labeling according to the CLP regulation.
Justification for selection of acute toxicity – oral endpoint
Study performed with a product containing approximately 90% of tetradecyl myristate and laurate.
Justification for classification or non-classification
Sonce both studies included in the dossier confirm that the LC50 for fatty alkyl esters is > 5000 mg/kg bw, the substance is not classified for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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