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Diss Factsheets
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EC number: 201-147-5 | CAS number: 78-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was done prior to GLP and testing guidelines. Thus, the report is lacking in detail, but was done at a highly reputable laboratory to the standards of the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The study was conducted pre-guideline, however, the format was similar to an OECD 401-type of study. Groups of rats were treated with a range of doses of the test article followed by 14 days of observation.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- iso-Butyronitrile
- IUPAC Name:
- iso-Butyronitrile
- Reference substance name:
- Isobutyronitrile
- EC Number:
- 201-147-5
- EC Name:
- Isobutyronitrile
- Cas Number:
- 78-82-0
- Molecular formula:
- C4H7N
- IUPAC Name:
- 2-methylpropanenitrile
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- None provided
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats were treated with a 10% aqueous solution of iso-Butyronitrile or a stock solution. The report is not clear in the results regarding which one is reported, so as a worst-case, we would assume that the results are for the 10% solution.
- Doses:
- 10-3200 mg/kg
- No. of animals per sex per dose:
- Not given
- Control animals:
- no
- Details on study design:
- Animals were administered a single dose of iso-butyronitrile by oral gavage, followed by a 14-day observation period.
Results and discussion
Effect levels
- Dose descriptor:
- approximate LD50
- Effect level:
- 50 mg/kg bw
- Clinical signs:
- other: Moderate to very weak, rapid and labored respiration, prostration, very severe vasodilation, especially in lower doses.
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US OSHA
- Conclusions:
- The observed LD50 was 50 mg/kg BW
- Executive summary:
Rats were treated with iso-butryonitrile by oral gavage with either stock test article or 10% in water. The report was not clear regarding which type of dose was reported, so the 10% solution is assumed as a worst case measure. The observed LD50 was 50 mg/kg BW
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