Registration Dossier
Registration Dossier
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EC number: 220-476-5 | CAS number: 2778-96-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute oral toxicity was carried out to study the effects of test chemical on rats.
- Author:
- Diamante et. al.
- Year:
- 2 010
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Octadecyl stearate
- EC Number:
- 220-476-5
- EC Name:
- Octadecyl stearate
- Cas Number:
- 2778-96-3
- Molecular formula:
- C36H72O2
- IUPAC Name:
- octadecyl octadecanoate
- Details on test material:
- - Name of test material:didodecyl 3,3'-sulfanediyldipropanoate (Dilauryl thiodipropionate)
- Molecular formula:C30H58O4S
- Molecular weight:514.85 g/mole
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rats at 2500 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value for acute oral toxicity test was considered to be >2500 mg/kg bw,when rats were treated with test chemical orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with test chemical orally. No mortality was observed in treated rats at 2500 mg/kg bw.Therefore, LD50 value was considered to be > 2500 mg/kg bw,when rat were treated with test chemical orally.
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