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EC number: 283-740-9 | CAS number: 84712-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 July 1979 to 16 July 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- EC Number:
- 283-740-9
- EC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- Cas Number:
- 84712-50-5
- Molecular formula:
- Not applicable (a generic molecular formula cannot be provided for this specific UVCB substance)
- IUPAC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: no data
- Stability under test conditions: no data
- Solubility and stability of the test substance in the solvent/vehicle: The test substance was used as supplied.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: young adult
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- single instillation
- Observation period (in vivo):
- The treated eyes were examined at 1, 2, 3, 5 and 7 days following instillation of the test material into the eyes.
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test material was not washed from the eyes.
- Time after start of exposure: not applicable
SCORING SYSTEM: According to the "Illustrated Guide for Grading Eye Irritation by Hazardous Substances".
TOOL USED TO ASSESS SCORE: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1, 2, 4, 5, 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The average ocular irritation score was 0.7 on day 1 post-instillation, then 0.0 for the rest of the observation period.
- Other effects:
- No other effects were observed.
Any other information on results incl. tables
Table 1: Individual daily scores.
Rabbit number |
Irritation parameter |
Readings day 1 |
Readings day 2 |
Readings day 3 |
Readings day 5 |
Readings day 7 |
1 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
1 |
Iris |
0 |
0 |
0 |
0 |
0 |
1 |
Conjunctivae |
0 |
0 |
0 |
0 |
0 |
1 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
2 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
2 |
Iris |
0 |
0 |
0 |
0 |
0 |
2 |
Conjunctivae |
0 |
0 |
0 |
0 |
0 |
2 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
3 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
3 |
Iris |
0 |
0 |
0 |
0 |
0 |
3 |
Conjunctivae |
1 |
0 |
0 |
0 |
0 |
3 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
4 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
4 |
Iris |
0 |
0 |
0 |
0 |
0 |
4 |
Conjunctivae |
0 |
0 |
0 |
0 |
0 |
4 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
5 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
5 |
Iris |
0 |
0 |
0 |
0 |
0 |
5 |
Conjunctivae (discharge) |
1 |
0 |
0 |
0 |
0 |
5 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
6 |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
6 |
Iris |
0 |
0 |
0 |
0 |
0 |
6 |
Conjunctivae |
0 |
0 |
0 |
0 |
0 |
6 |
Chemosis |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the eye irritation study, conducted according to a protocol similar to OECD TG 405 and in compliance with GLP, the test substance, Acetic acid, C11-14-isoalkyl esters, C13-rich, was reported to be not irritating to rabbit eyes.
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