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EC number: 203-406-8 | CAS number: 106-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Appearance/physical
state/colour:
On
the basis of physical observation, the substance 1-methylpiperidin-4-ol
was observed to be a colourless to pale yellow coloured liquid.
Freezing
point:
The
Mean Freezing point of 1-methylpiperidin-4-ol; CAS No. 106-52-5 was
determined with Method according to Cooling Curve and it was found to be
-11.24 °C at 970.2 hPa.
Boiling
point:
The
mean boiling point of 1-methylpiperidin-4-ol (CAS No. 106-52-5) was
determined to be 199.3°C at 971.5 hPa.
Density:
The
mean density of 1-methylpiperidin-4-ol (CAS No. 106-52-5) was determined
to be 0.9775 g/cm³ at 20°C and 971.7 hPa.
Particle
size distribution (Granulometry):
Accordance
with REACH Chapter R.7A Endpoint Specific Guidance, specifically
R.7.1.14.1 Information requirements on granulometry, the granulometry
study does not need to be conducted as the test substance,
1-methylpiperidin-4-ol is marketed or used in a non solid or granular
form. The test substance, 1-methylpiperidin-4-ol is a liquid at room
temperature and as such this study is not technically feasible. Hence
this endpoint was considered for waiver.
Vapour
pressure:
Modified
Grain method was used to estimate the vapour pressure of the test
chemical using MPBPVP v1.43 of EPI SUITE. The estimated vapor pressure
of 1-methyl-4-Piperidinol was 0.061 mm Hg = 8.13 Pa at 25°C.
Partition
Coefficient:
The
partition coefficient(n-octanol/water) of test substance
1-methylpiperidin-4-ol (CAS No. 106-52-5) was determined as per the HPLC
method (OECD Guideline-117). The Log Pow value was found to be 0.7556±
0.033 at 25°C.
Water
Solubility:
The
water solubility for the test item 1-methylpiperidin-4-ol was determined
to be 105579.95 mg/L at 30°C.
Surface
tension:
In
accordance with column 2 of Annex VII of the REACH regulation, this end
point was considered for waiver since surface activity is a not a
desired property of the material as use in pharmaceutical industry.
Flash
point:
The
mean flash point of 1-methylpiperidin-4-ol (CAS No. 106-52-5) was
determined to be 87.6°C at 971.0hPa.
Autoflammability:
1-methylpiperidin-4-ol
did not catch fire on being exposed to air at room temperature of 27°C
and pressure of 966 hPa. This indicates that 1-methylpiperidin-4-ol is
not auto-flammable.
Flammability:
1-methylpiperidin-4-ol
does not indicate any ignition when the flame of bunsen burner having
temperature of approximately 950°C is brought in contact with it. Thus
it can be concluded that 1-methylpiperidin-4-ol is not flammable at high
temperature. However since such high temperatures are not found under
normal circumstances of transportation and use, thus
1-methylpiperidin-4-ol was considered non-flammable for chemical safety
assessment.
Explosiveness:
In
accordance with column 2 of Annex VII of the REACH regulation, the study
does not need to be conducted since there are no chemical groups
associated with explosive properties present in the molecule of
1-methylpiperidin-4-ol. Thus, the chemical is likely to be "Non
explosive". Hence this end point was considered for waiver.
Oxidising
properties:
In
accordance with column 2 of Annex VII of the REACH regulation, the
substance 1-methylpiperidin-4-ol is incapable of reacting exothermically
with combustible materials on the basis of the chemical structure. It is
an organic substance containing oxygen but no halogen atoms and these
elements are not chemically bonded to nitrogen or oxygen. Thus, the
chemical is likely to be "Non-oxidising".
pH:
The
pH of 1% w/v solution of the test item 1-methylpiperidin-4-ol (CAS
No106-52-5) was determined to be 10.34 at 30°C.
Viscosity:
Kinematic
viscosity (experimental) of 1-methylpiperidin-4-ol (CAS No. 106-52-5)at
30°C and 50°C is determined to 44.3612mm²/sec and 38.1121mm²/s,
respectively.
Dynamic viscosity (calculated) of 1-methylpiperidin-4-ol (CAS No. 106-52-5)at 30°C and 50°C is determined to be 44.5963mPa.S and 38.3140mPa.S, respectively.
Additional information
Appearance/physical
state/colour:
On
the basis of physical observation, the substance 1-methylpiperidin-4-ol
was observed to be a colourless to pale yellow coloured liquid.
Other supporting data from safety data sheets by Sigma aldrich ,2014, and Fisher scientific ,2005 also indicates that the chemical 1-methylpiperidin-4-ol as clear light yellow colored liquid in appearance.
Freezing
point:
The
Freezing point determination of 1-methylpiperidin-4-ol (CAS No.106-52-5)
was done using crushed ice and salt. The determination was done on the
basis of cooling curve (time vs. temperature) obtained when the test
item was placed in the cooling bath. The freezing point was determined
to be -11.24°C at 970.2 hPa.
Based on other supporting data from safety data sheets and authoritative database, the freezing point of chemical 1-methylpiperidin-4-ol is determined to be in the range of 26°C to 31°C. As the data from lab has K1 reliability and the test was performed using standard methods of analysis which has the value of freezing point as -11.24°C, thus considered as key study for the chemical safety assessment.
Boiling
point:
The
boiling point determination of Test item 1-methylpiperidin-4-ol (CAS No.
106-52-5 ) was done as per the test guideline OECD 103. The method
followed was according to Siwoloboff. The mean boiling point was
determined to be 199.3°C at 971.5 hPa.
Other supporting studies from various authoritative database and safety data sheets, also indicates that the boiling point of chemical lies in the range of 186.4 - 200°C and the selected key study value 199.3°C lies between the range as mentioned above.
Density:
The
density of test item 1-methylpiperidin-4-ol (CAS No. 106-52-5)was
determined following OECD Guideline 109 and according to the IS 4730 :
1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids
(First Revision) using glass pycnometer. The mean density of test item
was determined to be 0.9775 g/cm³ at 20°C and 971.7 hPa.
Other supporting data from chemspider, 2012 and safety data sheet by sigma aldrich 2014, also indicates the density of chemical 1-methylpiperidin-4-ol to be 0.98 g/cm3.
Particle
size distribution (Granulometry):
Accordance
with REACH Chapter R.7A Endpoint Specific Guidance, specifically
R.7.1.14.1 Information requirements on granulometry, the granulometry
study does not need to be conducted as the test substance,
1-methylpiperidin-4-ol is marketed or used in a non solid or granular
form. The test substance, 1-methylpiperidin-4-ol is a liquid at room
temperature and as such this study is not technically feasible. Hence
this endpoint was considered for waiver.
Vapour
pressure:
Modified
Grain method was used to estimate the vapour pressure of the test
chemical using MPBPVP v1.43 of EPI SUITE. The estimated vapor pressure
of 1-methyl-4-Piperidinol was 0.061 mm Hg = 8.13 Pa at 25°C.
Partition
Coefficient:
The partition Coefficient n-octanol/water of 1-methylpiperidin-4-ol (CAS No.106-52-5) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, Nitrobenzene, Dodecanoic acid, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Diphenyl ether, Allyl phenyl ether having Pow value ranging from 1.9 to 4.6. The Log Pow value was found to be 0.7556± 0.033 at 25°C.
Other supporting information from various databases, suggests that the estimated log Pow of 1-methylpiperidin-4-ol was -0.14. Based on these values, it can be concluded that the test chemical,1-methylpiperidin-4-ol is hydrophillic in nature.
Water
Solubility:
The
water solubility determination of test item 1-methylpiperidin-4-ol (CAS
No. 106-52-5) was done as per the OECD guideline 105 by
spectrophotometric analytical method. The solubility of
(1-methylpiperidin-4-ol of 106-52-5) in water was determined to be
105579.95 mg/L at 30°C.
Other supporting datafrom various estimation models also suggests the estimated water solubility of 1 -methyl-4 -piperidinol was 1000000 mg/l at 25 deg C . Based on these values, 1-methylpiperidin-4-ol can be considered to be highly soluble in water.
Surface
tension:
In
accordance with column 2 of Annex VII of the REACH regulation, this end
point was considered for waiver since surface activity is a not a
desired property of the material as use in pharmaceutical industry.
Flash
point:
The
flash point determination of 1-methylpiperidin-4-ol (CAS No. 106-52-5)
was done following closed cup method using Pensky-Martens flash point
apparatus. The test was conducted in replicates and mean flash point was
determined to be 87.6°C at 971.0hPa.
As per the other supporting data for flash point from MSDS and
authoritative databases, the flash point value determined was in range
from 87°C to 112°C and the selected key
study value 87.6°C lies between the range as mentioned above. Also based
on criteria mentioned in CLP regulation the substance
1-methylpiperidin-4-ol was considered to be non flammable.
Autoflammability:
1-methylpiperidin-4-ol
did not catch fire on being exposed to air at room temperature of 27°C
and pressure of 966 hPa. This indicates that 1-methylpiperidin-4-ol is
not auto-flammable.
Flammability:
1-methylpiperidin-4-ol
does not indicate any ignition when the flame of bunsen burner having
temperature of approximately 950°C is brought in contact with it. Thus
it can be concluded that 1-methylpiperidin-4-ol is not flammable at high
temperature. However since such high temperatures are not found under
normal circumstances of transportation and use, thus
1-methylpiperidin-4-ol was considered non-flammable for chemical safety
assessment.
Explosiveness:
In
accordance with column 2 of Annex VII of the REACH regulation, the study
does not need to be conducted since there are no chemical groups
associated with explosive properties present in the molecule of
1-methylpiperidin-4-ol. Thus, the chemical is likely to be "Non
explosive". Hence this end point was considered for waiver.
Oxidising
properties:
In
accordance with column 2 of Annex VII of the REACH regulation, the
substance 1-methylpiperidin-4-ol is incapable of reacting exothermically
with combustible materials on the basis of the chemical structure. It is
an organic substance containing oxygen but no halogen atoms and these
elements are not chemically bonded to nitrogen or oxygen. Thus, the
chemical is likely to be "Non-oxidising".
pH:
The
pH determination of test item 1-methylpiperidin-4-ol (CAS No 106-52-5)
was done following OECD guideline 122. pH of 1% w/v solution was
measured with the help of pH meter and it was observed to be 10.34 at
30°C.
Viscosity:
The
viscosity determination of Test item 1-methylpiperidin-4-ol (CAS No.
106-52-5 ) was done as per the test guideline OECD 114 using Redwood
Viscometer No. 1. Kinematic viscosity (experimental) of Test item at
30°C and 50°C is 44.3612 mm²/sec and 38.1121 mm²/s, respectively.
Dynamic viscosity (calculated) of Test item at 30°C and 50°C is 44.5963
mPa.S and 38.3140 mPa.S, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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