Registration Dossier
Registration Dossier
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EC number: 700-372-0 | CAS number: 1128026-41-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at GLP-accredited facility to current guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- ca. 6.27
- Temp.:
- 30 °C
- pH:
- 7.1
- Details on results:
- The retention time of the test material (22.609 , 22.589 minutes) was slightly shorter than that of the most retained reference substance (DDT, 23.768 minutes). The log10Pow for DDT is 6.5. The calibration curve was linear over the range of reference chemicals, with a correlation coefficient of 0.997.
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test material has been determined to be 1.84 x 106 , log10 Pow 6.27.
- Executive summary:
The partition coefficient of the test material has been determined to be 1.84 x 106, log10Pow6.27, unsing HPLC method, Method A8 of Commission Directive 92/69/EEC.
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