Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-888-1 | CAS number: 75-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
NOAEC: 0.2 mg/L air (females only), however there was no NOAEL for males.
Key value for chemical safety assessment
Additional information
In a 4 week study four groups of 15 male and 15 female Sprague-Dawley rats per group were exposed to tertiary butylamine (TBA)vapor at 0, 0.2, 0.5 and 1.98 mg/L for six hours each workday for four weeks. Gross signs of toxicity were limited to the high exposure group and included an decrease in mean body weight, generally poor health, nasal irritation, respiratory difficulties and death in one male. In the high dose group other treatment-related effects observed were increased organ to body weight ratios for the brain in both sexes and for the adrenal and testes in males. According the report the „no-effect" (NOEC) level for both male and female rats was 0.5 mg/L t-butylamine vapor (Monsanto 1981; reliability score: 2).
In a 13 week study four groups of 15 male and 15 female Sprague-Dawley rats were exposed to TBA-vapor at 0, 0.2, 0.5 and 2.01 mg/L for 6h/d, each workday for a ca.13 week period. Clinical signs were similar to the 4 week study. Four male and 7 female rats in the high exposure group died or were sacrificed. High exposure male and female rats exhibited mild lymphopenia, neutrophilia, an elevation in liver associated enzymes and decreased blood glucose. Microscopic examinations revealed severe chronic inflammation of the trachea and a secondary increase in neutrophilic leucocytes of the bone marrow in the high exposure grou . The study showed an elevation in liver associated enzymes; ALP, SGOT and SGPT were increased in the high dose group. This suggests mild liver toxicity. There was no NOAEC for males; however, the NOAEC and LOAEC for females was 0.2 mg/L, the lowest dose tested, and 0.5 mg/L, respectively. (Monsanto 1985; reliability score: 2).
Justification for classification or non-classification
There is no need for classification based on repeated dose studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.