Registration Dossier
Registration Dossier
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EC number: 240-457-5 | CAS number: 16409-43-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study with limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity test in rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- EC Number:
- 221-217-9
- EC Name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- Cas Number:
- 3033-23-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- Details on test material:
- - Name of test material (as cited in study report): Rose oxide levo
- Other: stereoisomer of rose oxide
- Lot/batch No.: 73-222
no further data given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 3 (sex not specified)
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
no further data given
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: Slight erythema in 2/3 animals Moderate erythema in 1/3 animals Moderate edema in 3/3 animals
- Gross pathology:
- No data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
