Registration Dossier
Registration Dossier
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EC number: 211-448-3 | CAS number: 645-62-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Skin irritation was tested using an internal method (BASF-test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhex-2-enal
- EC Number:
- 211-448-3
- EC Name:
- 2-ethylhex-2-enal
- Cas Number:
- 645-62-5
- Molecular formula:
- C8H14O
- IUPAC Name:
- 2-ethylhex-2-enal
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethyl-hexen-2-al-1
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.96 - 3.1 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- An application site of 2.5 x 2.5 cm was covered.
- Duration of treatment / exposure:
- 1. Experiment: 1, 5, 15 minutes
2. Experiment: 20 hours - Observation period:
- up to 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1-2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within:
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 1-2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- severe irritant; corrosive properties cannot be fully excluded
Any other information on results incl. tables
Exposure time |
Results after 24 hours |
Results after 8 days |
1 min |
Redness 2 |
Redness 1 |
5 min |
Redness 2 |
Redness 1/ Scurf 2 |
15 min |
Redness 2 |
Necrosis1 / Scurf 2 |
20 hours |
Necrosis 1/ Redness 2 / Oedema 1 |
Necrosis 2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
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