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EC number: 211-806-9 | CAS number: 697-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from High Production Volume Information System (HPVIS)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity of Phenol, 2,4,6trimethyl- in rats
- Author:
- United States Environmental Protection Agency (EPA)
- Year:
- 2 017
- Bibliographic source:
- High Production Volume Information System (HPVIS)| OPPT | US EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- Acute oral toxicity study of Phenol, 2,4,6trimethyl-) in rats
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4,6-trimethylphenol
- EC Number:
- 208-419-2
- EC Name:
- 2,4,6-trimethylphenol
- Cas Number:
- 527-60-6
- IUPAC Name:
- 2,4,6-trimethylphenol
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): 2,4,6-trimethylphenol
- Molecular formula (if other than submission substance): C9H12O
- Molecular weight (if other than submission substance): 136.21 g/mol
- Substance type: Organic
- Physical state: solid
- Impurities (identity and concentrations): NA
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phenol, 2,4,6-trimethyl- (2,4,6-trimethylphenol )
- Molecular formula (if other than submission substance): C9H12O
- Molecular weight (if other than submission substance): 136.1928 g/mole
- Substance type: Organic
- Physical state: No data available
Purity 87.72%
- Impurities (identity and concentrations):O-Cresol = 0.11%;2,6 Xylenol = 0.81%; 2,4/2,5 Xylenol = 5.61%; 2,3,6-Trimethylphenol = 1.58%; 2,6 EMP = 4.03%; Unknowns = 4.17%) Measured
Test animals
- Species:
- rat
- Strain:
- other: rattus norvegicus
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: 8 weeks old
- Weight at study initiation: 201 to 221 g
- Fasting period before study: All animals were fasted the night prior to dosing.
- Diet (e.g. ad libitum): Following dosage, the rats were provided feed, ad libitum
- Water (e.g. ad libitum): Following dosage, the rats were provided water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2000 mg TMP/kg body weight
- Amount of vehicle (if gavage): 1 mL/100 gm body weight
- Justification for choice of vehicle: Cottonseed oil
DOSAGE PREPARATION (if unusual): The test substance was a solid and was suspended in cottonseed oil. The dose was calculated using a concentration of 1 gm/mL. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 male/ 3 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: Mortality, clinical signs, body weight and gross pathology. - Statistics:
- No data availableNo data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated male and female rat at 2000 mg/kg bw
- Clinical signs:
- other: Piloerection was observed in all test animals for the first day of the study. All signs of piloerection were resolved by Day 3 of the study in all but one animal, which was resolved by Day 4 of the study. No unusual clinical observations were observed for
- Gross pathology:
- No unusual lesions were observed in treated male and female rat.
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to > 2000 mg/kg bw when rattus norvegicus male and female rats were treated with Phenol, 2,4,6-trimethyl-orally by gavage.
- Executive summary:
In a acute oral toxicity study,rattus norvegicus male and femalerats were treated withPhenol, 2,4,6-trimethyl- in the concentration of 2000 mg/kg bw orally by gavage and observed for 14 days. No mortality was observed in treated male and female rat. Piloerection was observed in all test animals for the first day of the study. All signs of piloerection were resolved by Day 3 of the study in all but one animal, which was resolved by Day 4 of the study. No unusual clinical observations were observed for the rest of the study. All animals gained weight during the 14-day post-dose observation period. No unusual lesions were observed in treated male and female rat. Therefore,LD50 was estimated to > 2000 mg/kg bw whenrattus norvegicus male and femalerats were treated withPhenol, 2,4,6-trimethyl-orally by gavage.
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