Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-062-3 | CAS number: 40754-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Estimated LD50 was considered to be 170000 mg/kg bw when rat were treated disodium 4-oxo-2-sulfonato-5, 8, 11, 14-tetraoxahexacosan-1-oate orally.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from Danish QSAR
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction
- Principles of method if other than guideline:
- Prediction is done by using Danish QSAR (EPA Model)
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate
- Molecular formula (if other than submission substance): C22H42O10S.2Na
- Molecular weight (if other than submission substance): 542.594 g/mole
- Substance type: Organic - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 17000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 17 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to 17000 mg/kg bw when mice were treated with disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate orally
- Executive summary:
In a acute oral toxicity estimation done by using Danish QSAR (EPA Model),50 % mortality observed at 17000 mg/kg bw . Therefore,estimated LD50 was considered to be 170000 mg/kg bw when rat were treated with disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 170 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from Danish QSAR toolbox
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In different studies, disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo estimated and experiments in rodents, i.e. most commonly in rats for disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate along with the study available on structurally similar read across substance across substance Sodium 1-methoxycarbonylpentadecane-2-sulfonate (CAS: 4016-24-4)The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In prediction done by SSS (2017) using Danish QSAR (EPA Model), 50 % mortality observed at 17000 mg/kg bw . Therefore, estimated LD50 was considered to be 170000 mg/kg bw when rat were treated disodium 4-oxo-2-sulfonato-5, 8, 11, 14-tetraoxahexacosan-1-oate orally.
In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate. The LD50 was estimated to be 2074 mg/kg bw when Wistar female rats were orally exposed with 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate.
Also it is further supported experimental data by J-CHECK (Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, 2010), on structurally similar read across substance Sodium 1-methoxycarbonylpentadecane-2-sulfonate (CAS: 4016-24-4), Crj: CD(SD)IGS male and female rats were treated Sodium 1-methoxycarbonylpentadecane-2-sulfonate in the concentration of 0, 786, 983, 1229, 1536, 1920, 2400 mg/kg orally by gavage in Olive oil. Deaths was observed 6 to 24 hours after administration in male rats at 983, 1229, 1536, 1920, 2400 mg/kg and in female rats at 1536, 1920, 2400 mg/kg. Decreased locomotor activity, ptosis, diarrhea, soiling of the perineal region and piloerection were observed in treated groups. Most clinical signs in the survivors showed a tendency for recovery on the day following administration and all had disappeared after 6 days. In addition, Dose dependent decrease in body weights were observed in treated male and female rats. However, a tendency for recovery was noted 3 days after the administration. Distention of the stomach with a watery content was observed in most of the animals which died. Therefore, estimated LD50 was considered to be 170000 mg/kg bw when rat were treated disodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate orally.
Thus based on the above studies and predictions on 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate and its read across substances, it can be concluded that most of the LD50 value is greater than 2000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate can be Not classified for acute oral toxicity.
Justification for classification or non-classification
Thus, based on the above studies and predictions on 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate and its read across substances, it can be concluded that most of the LD50 value is greater than 2000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate can be Not classified for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.