Registration Dossier
Registration Dossier
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EC number: 228-958-7 | CAS number: 6379-72-2
Endpoint summary
Administrative data
Description of key information
One experimental study of reliability 4 (based on international guideline and GLP compliance) and two reliable QSAR models were used to assess the aquatic toxicity of the registered substance, (E)-1,2 -Dimethoxy-4 -prop-1 -en-1 -ylbenzene, to fish, aquatic invertebrates and algae.
In the experimental study on aquatic invertebrates Daphnia magna (NOACK, 2000), performed on the registered substance, the 48-EC50 value was determined at 25 mg/L (95% CL: 23 - 27 mg/L), based on nominal concentrations. The test substance was analytically verified only at the beginning of the test, using DOC analysis. No analytical verification of test concentrations was performed at the end of the test. The initial measured concentration at the nominal concentration of 25 mg/L was 16.26 mg/L. As some loss of test substance may be expected during the duration of the test, the mean measured 48h-EC50 value may be expected to be less than 16.26 mg/L. This result is completely in line with the QSAR results on aquatic invertebrates performed on the registered substance which are both very close to the measured value from the daphnid study.
The two QSAR models used were iSafeRat holistic approach v1.4 and ECOSAR v1.11 models. Both QSAR results, performed on the registered substance, were considered reliable as the substance falls within the applicability domain of the models. The results of each model are presented in the table below:
|
iSafeRat holistic approach v1.4 |
ECOSAR v1.11 |
Acute fish |
96h-LC50 = 12 mg/L (95% CL: 11-14 mg/L) |
96h-LC50 = 22.8 mg/L |
Acute daphnid |
48h-EC50 = 13 mg/L (95% CL: 12-14 mg/L) |
48h-LC50 = 14.0 mg/L |
Algae |
72h-ErC50 = 12 mg/L (95% CL: 11-14 mg/L) |
96h-EC50 = 14.8 mg/L |
The E(L)C50 key values, used for chemical safety assessment, were determined as the geometric mean of predicted E(L)C50 values and, when available, measured value (for aquatic invertebrates), corresponding to 16.5 mg/L for fish, 14.4 mg/L for aquatic invertebrates and 13.3 mg/L for algae.
Finally, the registered substance is readily biodegradable and no inhibition effects of the activity of microorganisms was observed in the biodegradation study at 100 mg/L. Therefore, in accordance with column 2 of REACH Annex VIII, the activated sludge respiration inhibition test does not need to be conducted.
Additional information
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