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EC number: 203-687-7 | CAS number: 109-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 401 with neligabgle restrictions mostly due to reduced reporting in times before GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Propyl chloroformate
- EC Number:
- 203-687-7
- EC Name:
- Propyl chloroformate
- Cas Number:
- 109-61-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- propyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): n-Propylchlorkohlensaeureester
- Physical state: liquid
- Analytical purity: not reported
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hagemann + Wiga
- Mean weight per group at study initiation: 190-240 g (male); 160-180 g (females)
- Fasting period before study: 15 -20 h
- Diet (e.g. ad libitum): Merilan MRH-Haltung; Eggersmann KG
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.93; 2.0; 2.9; 13.6; 20.0; 29.4; 43.0; 63.2
MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg eaquals ca. 1.2 ml/rat - Doses:
- 3160.0; 2150.0; 1470.0; 1000.0; 681.0; 147.0; 100.0; 46.4 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mean body weight and observation of clinical signs was performed several times on the day of administration and once daily afterwards with the except on weekends and on holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- according to Finney, D.J., Probit Analysis, Cambridge University Press, 3rd edition, 1971
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 210 mg/kg bw
- 95% CL:
- 1 055.4 - 1 391.3
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 1 500 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- 95% CL:
- 741.5 - 1 546.6
- Mortality:
- 46.4 mg/kg: no mortality observed
100 mg/kg: no mortality observed
147 mg/kg: no mortality observed
681 mg/kg: 1/5 females died within 2 d; no mortality observed in males
1000 mg/kg: 1/5 females died within 1 d; no mortality observed in males
1470 mg/kg: 4/5 females died within 1 d; 5/5 males died within 1 d
2150 mg/kg: 10/10 animals died within 1 d
3160 mg/kg: 10/10 animals died within 1 d - Clinical signs:
- other: 46.4 mg/kg: no treatment related effects 100 mg/kg: no treatment related effects 147 mg/kg: aggressiveness 681 mg/kg: dyspnoea, stertor (respiratory noise), apathy, staggering, tremors, piloerection, salivation, poor general state 1000 mg/kg: dyspnoea, ap
- Gross pathology:
- Animals that died:
Heart: acute dilatation on the right side; acute passive hyperemia; stomach: necrotic white mucosa (necrotic corrosive gastritis); intestines: necrotic white mucosa (necrotic corrosive gastritis)
Sacrificed animals:
46.4 - 147 mg/kg: Organs: no abnormalities detected
1000 and 1470 mg/kg: Forestomach: diverticularization, in some cases with scabs/crusts and in some cases adhesions between the forestomach and spleen, liver and peritoneum
Applicant's summary and conclusion
- Executive summary:
The study is comparable to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP. Groups of 5 rats per sex and dose were administered 46.4, 100, 147, 681, 1000, 1470, 2150 and 3160 mg/kg of the test substance.
The acute LD50 for female rats is 1210 mg/kg (males & females) after oral application (males: 1000 - 1500 mg/kg; females: 1100 mg/kg). No mortality was observed at doses up to 147 mg/kg. Mortality and dyspnoea, apathy, staggering, piloerection and general poor state were observed as main clinical signs in treatments of 681 mg/kg and higher. In died animals, acute heart dilatation on the right side, acute passive hyperemia, necrotic white mucosa in stomach and intestine was observed.
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