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EC number: 940-393-4 | CAS number: 1702355-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-dibutyl-N,N'-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamine
- EC Number:
- 940-393-4
- Cas Number:
- 1702355-94-9
- Molecular formula:
- C35 H66 N8
- IUPAC Name:
- N,N'-dibutyl-N,N'-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamine
- Test material form:
- solid: bulk
- Details on test material:
- - State of aggregation: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Germany
- Age at study initiation: 10 weeks
- Fasting period before study: 16h before administration
- Housing: single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6 and 40 g/ 100 ml, respectively
- Amount of vehicle (if gavage): 5 ml/ kg bw
- Justification for choice of vehicle: good homogeneity
MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg bw - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of administration and at least once during each workday thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Mortality:
- One animal was sacrificed in a moribund state on study day 3, while the two animals were sacrificed in a moribund state on study day 6. No mortality occurred in both 300 mg/kg bw test groups.
- Clinical signs:
- In all animals of the 2000 mg/kg bw test group impaired general state was noted from hour 2 or 3 until hour 5 and was noted again in two animals on study day 3. Poor general state was noted in all animals on study day 3 or 6, respectively.
Piloerection was observed in all animals from hour 2 or 3 until hour 5 and was noted in one animal on study day 3 again while two animals showed this finding from study day 3 until study day 6. Dyspnoea and exsiccosis were noted on study day 3 in all animals and persisted in two of these animals up to study day 6. Staggering, loss of body weight and chromodacryorrhea were observed in all animals on study day 3 or 6, respectively. Reduced defecation was observed in two animals from study day 3 until study day 6, while diarrhea and feces smeared fur were noticed in these animals on study day 6. On the same day one of these animals showed yellowish discoloration of feces. On study day 3 one animal showed urine smeared fur and lack of defecation.
In the first 300 mg/kg bw test group one animal showed impaired general state, piloerection and chromodacryorrhea on study day 1 after administration. In the second 300 mg/kg bw test group one animal showed impaired general state and piloerection on study day 2. - Body weight:
- The mean body weight of the surviving animals increased within the normal range throughout the study period with one exception in the second 300mg/kg test group. This animal revealed a stagnation of body weight in the second week.
- Gross pathology:
- In the 2000 mg/kg bw test group the following macroscopic pathologic findings were observed in the animals sacrificed in a moribund state: spotted, light discolored liver in all animals, red discoloration of the glandular stomach in two animals and yellowish discoloration of the appendix content in one animal. There were no macroscopic pathological findings in the surviving animals sacrificed at the end of the observation period (300 mg/kg bw: 6 females).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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