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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Starting Date: 20 July 2012; Experimental Completion Date: 23 January 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- other: solid
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Preparation of the Test Solutions:
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 0.500 g/L in the three buffer solutions.
The concentration of each solution did not exceed the lesser of 0.01 mol/L or half the water solubility.
The test solutions were split into individual vessels for each data point.
The solutions were shielded from light whilst maintained at the test temperature
Preliminary test/tier 1:
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 120 hours.
Tier 2:
Results from the preliminary test/tier 1 showed it was necessary to undertake further testing at pH 9. Sample solutions were maintained at 50.0 ± 0.5, 60.0 ± 0.5 °C and 70.0 ± 0.5 °C for periods of 239 hours, 141¼ hours and 48 hours respectively.
Analysis of sample solutions:
Duplicate vessels of sample solutions for each pH were taken from the waterbath at various times and the pH of each solution recorded. The concentration of the sample solution was determined by high performance liquid chromatography (HPLC).
Samples:
An aliquot of each pH 4 and pH 7 sample solution was diluted by a factor of 10 using dimethyl sulfoxide.
An aliquot of each pH 9 sample solution was diluted by a factor of 10 using acidified dimethyl sulfoxide.
Standards:
For pH 4 and pH 7 sample solution analysis, duplicate standard solutions of test item were prepared in dimethyl sulfoxide: relevant buffer solution (90:10 v/v) at a nominal concentration of 50 mg/L.
For pH 9 sample solution analysis, duplicate standard solutions of test item were prepared in acidified dimethyl sulfoxide : pH 9 buffer solution (90:10 v/v) at a nominal concentration of 50 mg/L.
Matrix blanks:
For pH 4 and pH 7 sample solution analysis, dimethyl sulfoxide: relevant buffer solution (90:10 v/v).
For pH 9 sample solution analysis, acidified dimethyl sulfoxide: pH 9 buffer solution (90:10 v/v). - Buffers:
- The test system uses sterile buffer solutions at pH's 4.0, 7.0 and 9.0
Specification of buffer solutions:
Buffer Solution (pH 4)
Components: Citric acid, Sodium chloride, Sodium hydroxide
Concentration (mol dm-3): 0.06, 0.04, 0.07
Buffer Solution (pH7)
Components: Disodium hydrogen orthophosphate (anhydrous), Potassium dihydrogen orthophosphate, Sodium chloride
Concentration (mol dm-3): 0.03, 0.02, 0.02
Buffer Solution (pH9)
Components: Disodium tetraborate, Sodium chloride
Concentration (mol dm-3): 0.01, 0.02 - Details on test conditions:
- Refer to details on sampling and analytical methods.
Duration of testopen allclose all
- Duration:
- 120 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.478 - 0.504 g/L
- Duration:
- 239 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.534 g/L
- Duration:
- 141.25 h
- pH:
- 9
- Temp.:
- 60 °C
- Initial conc. measured:
- 0.534 g/L
- Duration:
- 48 h
- pH:
- 9
- Temp.:
- 70 °C
- Initial conc. measured:
- 0.516 g/L
- Number of replicates:
- Duplicate
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- See any other information on results incl. tables.
- Test performance:
- Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 100 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained for the analysis matrices relevant to all three pHs. - Transformation products:
- not measured
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 82.7 d
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- See any other information on results incl. tables.
Any other information on results incl. tables
Results
Preliminary test/Tier 1
The mean peak areas relating to the standard and sample solutions are shown in attached background material.
The test item concentrations at the given time points are shown in the following tables:
pH 4 at 50.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
% of Mean Initial Concentration |
Initial |
A |
0.504 |
100 |
B |
0.504 |
100 |
|
24 |
A |
0.515 |
102 |
B |
0.516 |
102 |
|
120 |
A |
0.510 |
101 |
B |
0.508 |
101 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 7 at 50.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
% of Mean Initial Concentration |
Initial |
A |
0.495 |
99.8 |
B |
0.497 |
100 |
|
24 |
A |
0.500 |
101 |
B |
0.500 |
101 |
|
120 |
A |
0.471 |
95.1 |
B |
0.471 |
95.0 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 9 at 50.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
% of Mean Initial Concentration |
Initial |
A |
0.478 |
99.6 |
B |
0.481 |
100 |
|
24 |
A |
0.416 |
86.7 |
B |
0.412 |
85.9 |
|
120 |
A |
0.242 |
50.6 |
B |
0.242 |
50.4 |
Result: The extent of hydrolysis after 120 hours indicated that a further test (Tier 2), conducted at 50.0, 60.0 and 70.0°C, was required to estimate the rate constant and half-life.
Tier 2
The mean peak area relating to the standard and sample solutions are shown in attached background material.
The test item concentrations at the given time points are shown in the following tables:
pH 9 at 50.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
Log10[concentration (g/L)] |
% of Mean Initial Concentration |
Initial |
A |
0.534 |
-0.272 |
99.9 |
B |
0.535 |
-0.272 |
100 |
|
51¼ |
A |
0.386 |
-0.414 |
72.1 |
B |
0.387 |
-0.412 |
72.4 |
|
72 |
A |
0.341 |
-0.467 |
63.8 |
B |
0.339 |
-0.470 |
63.4 |
|
118 |
A |
0.257 |
-0.589 |
48.1 |
B |
0.261 |
-0.583 |
48.8 |
|
168 |
A |
0.196 |
-0.709 |
36.6 |
B |
0.195 |
-0.710 |
36.4 |
|
239 |
A |
0.132 |
-0.880 |
24.7 |
B |
0.131 |
-0.882 |
24.6 |
Result: Slope = -2.54 x 10-4 (see Figure 3.4 - Graph of log10 Concentration (g/L) versus Time (Hours) - attached background material).
kobs = 5.84 x 10-3 hour-1
= 1.62 x 10-6 second-1
t½ = 119 hours
pH 9 at 60.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
Log10[concentration (g/L)] |
% of Mean Initial Concentration |
Initial |
A |
0.534 |
-0.272 |
99.9 |
B |
0.535 |
-0.272 |
100 |
|
24 |
A |
0.354 |
-0.451 |
66.3 |
B |
0.354 |
-0.451 |
66.2 |
|
48 |
A |
0.241 |
-0.618 |
45.1 |
B |
0.240 |
-0.620 |
44.9 |
|
72 |
A |
0.175 |
-0.758 |
32.7 |
B |
0.167 |
-0.776 |
31.3 |
|
96 |
A |
0.116 |
-0.934 |
21.8 |
B |
0.116 |
-0.934 |
21.8 |
|
118 |
A |
8.10 x 10-2 |
-1.091 |
15.2 |
B |
8.03 x 10-2 |
-1.095 |
15.0 |
|
141¼ |
A |
5.40 x 10-2 |
-1.268 |
10.1 |
B |
5.32 x 10-2 |
-1.274 |
9.96 |
Result: Slope = -6.97 x 10-3 (see Figure 3.5 - Graph of log10 Concentration (g/L) versus Time (Hours) - attached background material).
kobs = 1.60 x 10-2 hour-1
= 4.46 x 10-6 second-1
t½ = 43.2 hours
pH 9 at 70.0 ± 0.5 ºC
Timepoint (hours) |
Sample Replicate |
Concentration (g/L) |
Log10[concentration (g/L)] |
% of Mean Initial Concentration |
Initial |
A |
0.516 |
-0.287 |
99.9 |
B |
0.517 |
-0.286 |
100 |
|
3 |
A |
0.461 |
-0.336 |
89.2 |
B |
0.460 |
-0.337 |
89.1 |
|
5½ |
A |
0.408 |
-0.389 |
79.0 |
B |
0.413 |
-0.384 |
80.0 |
|
22½ |
A |
0.202 |
-0.695 |
39.1 |
B |
0.202 |
-0.694 |
39.2 |
|
25½ |
A |
0.179 |
-0.747 |
34.6 |
B |
0.180 |
-0.745 |
34.8 |
|
28½ |
A |
0.159 |
-0.799 |
30.8 |
B |
0.160 |
-0.797 |
30.9 |
|
48 |
A |
7.12 x 10-2 |
-1.148 |
13.8 |
B |
7.10 x 10-2 |
-1.149 |
13.8 |
Result: Slope = -1.80 x 10-2 (see Figure 3.6 - Graph of log10 Concentration (g/L) versus Time (Hours) - attached background material).
kobs = 4.14 x 10-2hour-1
= 1.15 x 10-5 second-1
t½ = 16.7 hours
The Arrhenius plot was constructed using the data shown in the following table:
pH 9 Arrhenius Data
T (ºC) |
T (K) |
1 / T (K) |
kobs (hr-1) |
Ln kobs |
50.0 |
323.15 |
3.10 x 10-3 |
5.84 x 10-3 |
-5.143 |
60.0 |
333.15 |
3.00 x 10-3 |
1.60 x 10-2 |
-4.133 |
70.0 |
343.15 |
2.91 x 10-3 |
4.14 x 10-2 |
-3.184 |
From the graph (Figure 3.7 - Graph of In.kobs versus 1/T (K), attached background material) of the above data, the rate constant and half-life at 25°C have been estimated to be as follows:
kobs = 3.49
x 10-4 hour-1
= 9.71
x 10-8 second-1
t½ = 1.98
x 103 hours
= 82.7
days
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrolysis characteristics of the test item have been quantified for the substituted-(naphthalen-1-methyl)heteromonocyclic chloride content of the test item. The rate constant and estimated half-life at 25 °C of the test item are summarised below:
The rate constant and estimated half-life at 25 °C of the test item are:
pH 4: Rate constant (s-1): not applicable
Estimated half-life at 25°C: >1 year
pH 7: Rate constant (s-1): not applicable
Estimated half-life at 25°C: >1 year
pH 9: Rate constant (s-1): 9.71 x 10-8
Estimated half-life at 25°C: 82.7 days
No hydrolysis testing was relevant to the propane-1,2-diol content of the test item, as it did not contain any hydrolysable functional groups and also from available information, it was expected to be readily biodegradable. - Executive summary:
Method:
The determination was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004, and Method 835.2120 of the OPPTS Guidelines.
The test system uses sterile buffer solutions at pH’s 4.0, 7.0 and 9.0.
Results
The hydrolysis characteristics of the test item have been quantified for the substituted-(naphthalen-1-methyl)heteromonocyclic chloride content of the test item. The rate constant and estimated half-life at 25°C of the test item are shown in the following table:
pH
Rate constant (s-1)
Estimated half-life at 25°C
4
not applicable
>1 year
7
not applicable
>1 year
9
9.71 x 10-8
82.7 days
No hydrolysis testing was relevant to the propane-1,2-diol content of the test item, as it did not contain any hydrolysable functional groups and also from available information, it was expected to be readily biodegradable.
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