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EC number: 212-668-2 | CAS number: 842-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from various prediction models and autoritative database
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Prediction done using BCFBAF Program (v3.01), PBT profiler and INERIS database
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: C.I. Solvent Yellow 14
- Molecular formula: C16 H12 N2 O
- Molecular weight: 248.284 g/mol
- Smiles notation: c12c(\N=N\c3ccccc3)c(ccc1cccc2)O
- InChl: 1S/C16H12N2O/c19-15-11-10-12-6-4-5-9-14(12)16(15)18-17-13-7-2-1-3-8-13/h1-11,19H/b18-17+
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Test temperature:
- 25 deg.C
- Reference substance (positive control):
- not specified
- Key result
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- 10 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.
- Executive summary:
Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.Based on the BCF concentration it is concluded that the test chemical 1-phenylazo-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Reference
BCFBAF Program (v3.01) Results:
==============================
SMILES : Oc(ccc(c1ccc2)c2)c1N=Nc(cccc3)c3
CHEM : 2-Naphthalenol, 1-(phenylazo)-
MOL FOR: C16 H12 N2 O1
MOL WT : 248.29
--------------------------------- BCFBAF v3.01 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 1.00 (BCF = 10 L/kg wet-wt)
Biotransformation Half-Life (days) : 1.67 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 2.83 (BAF = 670 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 5.51
Equation Used to Make BCF estimate:
Log BCF = 1.00 { Aromatic Azo Specification }
Correction(s): Value
Aromatic Azo compound 0.000
Estimated Log BCF = 1.000 (BCF = 10 L/kg wet-wt)
Description of key information
Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical 1-phenylazo-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Key value for chemical safety assessment
- BCF (aquatic species):
- 10 L/kg ww
Additional information
Bioaccumulation: aquatic / sediment
Experimental and estimated data of Bioaccumulation property for the target chemical 1-phenylazo-2-naphthol (CAS No. 842-07-9) and its read across chemical were reviewed to summarize as follows:
From predicted model EPI suite 2017 using BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.Based on the BCF concentration it is concluded that the test chemical 1-(phenyldiazenyl)-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
From HSDB database; 2017 the read across chemical Sodium 4-[(4-hydroxy-1-naphthyl)azo] benzene sulphonate i.e C.I. ACID ORANGE 20 (CAS No. 523-44-4) indicate an estimated BCF value of 0.5 was calculated for C.I. Acid Orange 20, using an estimated log Kow of -0.14 and a recommended regression-derived equation. According to a classification scheme, this BCF value suggests that bioconcentration in aquatic organisms is low.
Data for another read across Orange G (CAS No. 1936-15-8) from same database i.e HSDB indicate that the estimated BCF value of 0 was calculated for Orange G, using an estimated log Kow of -4.56 and a recommended regression-derived equation. This BCF value suggests that bioconcentration of Orange G in aquatic organisms will not be an important fate process.
Similarly information for another read across C.I. Food Yellow 3 (CAS No. 2783-94-0) indicates the ionic character of C.I. Food Yellow 3 suggests the potential for bioconcentration in aquatic organisms is expected to be low.
Thus, based on the above all studies it is concluded that the test substance 1-phenylazo-2-naphthol (CAS No. 842-07-9) is non bioaccumulative in aquatic environment.
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