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EC number: 213-909-4 | CAS number: 1066-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin irritation (OECD 404): not irritating
eye irritation (OECD 405): not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The read-across substance Niacin bound Chromium (ChromeMate CM-100M) was investigated in an acute dermal irritation study performed equivalent to OECD 404 and GLP (Shara, 2005). The test substance dissolved in corn oil was applied to the shaved skin of one male and two New Zealand Albino rabbits under semiocclusive conditions for 4 hours. 1 h after the application, very-slight erythema was observed at all three treated sites. The overall incidence and severity of irritation decreased with time. All animals were free from dermal irritation within 48 h. Apart from the dermal irritation noted, all animals appeared active and healthy and with no other signs of gross toxicity. Therefore, the source substance was considered to be not irritating to the skin under the conditions of this test. In addition, an acute dermal toxicity study performed with the Acetic acid, chromium salt, basic does not indicate skin irritation up to the limit dose level of 2000 mg/kg body weight (Seguier, 2008).
Eye irritation/corrosion
A HET-CAM was performed with Acetic acid, chromium salt, basic which revealed no corrosive effects (Paulus and Rudolf, 2008).
In addition, Niacin bound chromium (ChromeMate CM-100M) was investigated in an acute eye irritation study performed equivalent to OECD 405 and GLP (Shara, 2005). 0.1 mL of the substance dissolved in water was applied to the conjuctival sac of one 1 male and two female rabbits. The untreated eye served as control. The eyes were investigated 1, 24, 48, and 72 h post-installation. No corneal opacity or iritis was observed in any treated eye during the study. One hour following test substance instillation, all treated eyes exhibited conjunctivitis. All animals were free of ocular irritation within 24 h. Apart from the eye irritation noted, all animals appeared active and healthy and with no other signs of gross toxicity. Therefore, the source substance was considered to be not irritating to the eye under the conditions of this test.
Justification for selection of skin irritation / corrosion endpoint:
Hazard assessment is conducted by means of read-across from a structural analogue/surrogate. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall quality assessment (refer to the endpoint discussion for further details).
Justification for selection of eye irritation endpoint:
Hazard assessment is conducted by means of read-across from a structural analogue/surrogate. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall quality assessment (refer to the endpoint discussion for further details).
Justification for classification or non-classification
The available data on the skin and eye irritation do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and is therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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