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EC number: 276-292-0 | CAS number: 72017-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experiment Start date: 25 January,1994 to Experiment End date: 27 January, 1994: Study Completion date: 25 May, 1994.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test substance:: FAT - 20202/E
Batch No.: Op.161
Purity: 70.1 %
Appearance: solid
Solubility: 100g/l [ in water]
Storage: room temperature
Expiration date: 03/98 - Analytical monitoring:
- yes
- Details on sampling:
- All test medium samples for the analytical determinations were taken after mixing of the test solutions from the approximate center of the test vessels and kept at -18 °C to -25 °C until analyses.
- Vehicle:
- yes
- Details on test solutions:
- Stock solution
0.5 g test substance were mixed with 200 ml test medium and fill up to 500 ml with test medium.
The stock solution was homogenized for 5 minutes in the ultrasonics bath.
Test concentrations
Based on a pretest, the test concentrations were chosen as 10, 18, 32, 58, 100 and 180 mg test article /l nominal. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The organism used in this test system is the species Daphnia magna. The Daphnia were bred in the testing facility of the Product Ecology TF, Textile Dyes Division under standardised conditions.
Breeding:
Cultures of Daphnia magna are maintained in glass vessels containing aprox. 3.0 I of reconstituted water ( see test medium ) at 18 - 22 °C. The waterwas renewed partially three times weekly. The Daphnia were feed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantités that the food was consumed within 24 h.
Pretreatment:
24 hours before the start of the exposure reproductive Daphnia were separated from the young Daphnia by sieving all individuals through a 710 µm sieve.
The quality of the Daphnia is checked at least every 3 months by determining the EC50 values (24 h) for potassium dichromate (range: 0.8 -1.5 mg/l).
For each concentration, of test substance, 20 Daphnia divided in two groups of 10 animals are used. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- 136 mg/l CaC03
- Test temperature:
- 21 ± 1 °C
- pH:
- 7.8 - 8.2.
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- Based on a pretest, the test concentrations were chosen as 10, 18, 32, 58, 100 and 180 mg test article /l nominal.
- Details on test conditions:
- 48 hours at 21 °C, 16 hours light / 8 hours dark
The Daphnia were exposed to the test article in 250 ml beakers containing 100 - 200 ml test medium with 10 animals per beaker. All tests are running in duplicate. During exposure the animals were kept at 21 ± 1 °C with 16 hours illumination. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 9.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 33.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 177.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Calculation of EC - values The reported results are related to the analytical concentrations of the test article. During test duration the test article concentrations in the analysed test media were in the range of 93.0 - 99.4 % of the nominal values. Therefore, under test conditions the test article was sufficiently stable. In all test concentrations non alteration of the test substance was observed after 48 hours.The EC0 value is at least 9.4 mg/l, the EC100 value is 177.4 mg/l after 48 hours.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EC50 and NOEC values were determined to 33.4 mg/L and 9.4 mg/L, respectively.
- Executive summary:
The acute toxicity of FAT 20202/E to Daphnia magna was determined in a 48-hours static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 84/449, L 251, Part C 2. The nominal concentrations tested were 10, 18, 32, 58, 100 and 180 mg test article / l, and a control without any additions. The reported results are related to the analytical concentrations of the test article. During test duration the test article concentrations in the analysed test media were in the range of 93.0 - 99.4 % of the nominal values. Therefore, under test conditions the test article was sufficiently stable. In all test concentrations non alteration of the test substance after 48 hours was observed. In the control, one Daphnia was immobilized after 48 hours, this effect is within the tolerance limit of 10 %. The % immbolization observed were 0, 20, 55, 80, 90 and 100 at 10, 18, 32, 58 100 and 180 mg/l respectively. Based on these findings, the EC0 value is at least 9.4 mg/l, but might even be higher than this concentration. The EC100 values is 177.4 mg/l after 48 hours. The 48 hour EC50 and NOEC values were determined to 33.4 mg/L and 9.4 mg/L, respectively.
Reference
Immobilisation of Daphnia
Conc. of Test Substance (mg/actual) |
No. of animals | No. of Responses | % immobility | ||
24hr | 48hr | 24hr | 48hr | ||
Blank | 10 | 0 | 1 | 0 | 5 |
10 | 0 | 0 | |||
9.4 | 10 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | |||
17.5 | 10 | 0 | 1 | 0 | 20 |
10 | 0 | 3 | |||
31.6 | 10 | 2 | 4 | 25 | 55 |
10 | 3 | 7 | |||
57.1 | 10 | 3 | 8 | 40 | 80 |
10 | 5 | 8 | |||
99 | 10 | 3 | 10 | 30 | 90 |
10 | 3 | 8 | |||
177.4 | 10 | 5 | 10 | 50 | 100 |
10 | 5 | 10 |
Analytical results of the test substance
Conc. Start | Conc. end | ||||
Nominal Conc. mg/l | mg/l | % of nominal | mg/l | % of nominal | average conc. mg/l |
10 | 9.5 | 95 | 9.3 | 93 | 9.4 |
18 | 17.6 | 97.8 | 17.3 | 96.1 | 17.5 |
32 | 31.8 | 99.4 | 31.4 | 98.1 | 31.6 |
58 | 57.2 | 98.6 | 57 | 98.3 | 57.1 |
100 | 98.9 | 98.9 | 99 | 99 | 99 |
180 | 177.1 | 98.4 | 177.7 | 98.7 | 177.4 |
Description of key information
The 48 hour EC50 and NOEC values were determined to 33.4 mg/L and 9.4 mg/L, respectively.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 33.4 mg/L
Additional information
The acute toxicity of FAT 20202/E to Daphnia magna was determined in a 48-hours static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 84/449, L 251, Part C 2. The nominal concentrations tested were 10, 18, 32, 58, 100 and 180 mg test article / l, and a control without any additions. The reported results are related to the analytical concentrations of the test article. During test duration the test article concentrations in the analysed test media were in the range of 93.0 - 99.4 % of the nominal values. Therefore, under test conditions the test article was sufficiently stable. In all test concentrations non alteration of the test substance after 48 hours was observed. In the control, one daphnid was immobilized after 48 hours, this effect is within the tolerance limit of 10 %. The % immbolization observed were 0, 20, 55, 80, 90 and 100 at 10, 18, 32, 58 100 and 180 mg/l, respectively. Based on these findings, the EC0 value is at least 9.4 mg/l, but might even be higher than this concentration. The EC100 values is 177.4 mg/l after 48 hours. The 48 hour EC50 and NOEC values were determined to 33.4 mg/L and 9.4 mg/L, respectively.
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