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EC number: 604-351-6 | CAS number: 143390-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- GLP compliance:
- yes
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): LAB 242 009. BAS 490 F
- Analytical purity: 99.6%
- Batch: Prep.-No. 353.01
- Radiochemical purity (if radiolabelling): > 99%
- Specific activity (if radiolabelling): 3566.0 MBq/g
- Locations of the label (if radiolabelling): (E)-2-[2-(2-Methylphenoxy)-methyl]phenyl-[phenyl-U- 14C]-2-(methoxyimido)acetic acid methyl ester
- Lot No.: 39/149-1
Constituent 1
- Radiolabelling:
- yes
Study design
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on matrix:
- PROPERTIES
- Four soil were used with the following properties:
- #Soil 1:
- Origin: Lufa Speyer German Standard Soil 2.1
- Type: sand
- Carbon content: 0.7%
- pH-value: 6.1
- Particle < 20 µm: 7.9%
- Cation-exchange Capacity [mVal/100 g soil]: 4.9
- #Soil 2:
- Origin: Lufa Speyer German Standard Soil 2.2
- Type: loamy sand
- Carbon content: 2.29%
- pH-value: 6.0
- Particle < 20 µm: 10.7%
- Cation-exchange Capacity [mVal/100 g soil]: 9.7
- #Soil 3:
- Origin: Lufa Speyer German Standard Soil 2.3
- Type: sandy loam
- Carbon content: 1.2%
- pH-value: 6.2
- Particle < 20 µm: 23%
- Cation-exchange Capacity [mVal/100 g soil]: 12.7
- #Soil 4:
- Origin: Limburgerhof Bruch Ost
- Type: clayey loam
- Carbon content: 2.7%
- pH-value: 7.5
- Particle < 20 µm: 53%
- Cation-exchange Capacity [mVal/100 g soil]: 46.1 - Details on test conditions:
- STOCK SOLUTION
- 4.0 mg test substance was dissolved in 25 ml CH3OH.
- Concentration of the test substance in the stock solution: 0.2 mg/ml CH3OH
- Specific radioactivity: 43209 dpm/µg
RECOVERY TEST IN AQUEOUS SOIL EXTRACTS
- Pretreatment: 50 g soil were shaken with 250 ml 0.01 M aqueous CaCl solution and the water extract was decanted.
- Testing concentrations: 25 ml of the water extract were fortified with stock solution in four different concentrations equal to 0.008, 0.04, 0.2 and 1 mg/L.
- Analysis: LSC
ADSORPTION SCREENING TEST
- 5 g soil were shaken with 25 ml 0.01 M aqueous CaCl solution containing 1 mg/L test substance. Water extract was decanted and analyzed by LSC
DESORPTION SCREENING TEST
- Pretreatment: Soil residue from adsorption screening test was made up with 25 ml 0.01 M aqueous CaCl solution and agitated for 16 hours. The supernatant was stored and the procedure was repeated. Both water extracts were combined and brought up to 50 ml with aqueous CaCl solution.
- Analysis: LSC
ADSORPTION EQUILIBRIUM TEST
- A series of samples for each soil with 1 mg/L test substance concentration were prepared. The samples were analyzed after 1, 2, 4, 8, 16 and 24 hours.
ADSORPTION ISOTHERM DETERMINATION
- Following the procedures of the adsorption screening test four initial test substance concentrations of to 0.008, 0.04, 0.2 and 1 mg/L were used for each soil. Agitation time = 1 h.
MATERIAL BALANCE
- Pretreatment: The amount of test substance adsorbed to soil was determined. Soil residue of the 1 mg/L samples from the adsorption isotherm determination was extracted by shaking with 25 ml methanol. After decanting the supernatant, the soil residues were extracted again. An aliquot of 1 ml from the combined extracts were analyzed.
- Analysis: LSC
Results and discussion
Adsorption coefficient
- Type:
- Koc
- Value:
- 219 - 372
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Adsorption constant KA = 2.6 - 7.7
Adsorption exponent 1/n = 0.95 - 0.99 - Recovery of test material:
- Recovery ranges from 100.0 to 112.6%
- Details on results (Batch equilibrium method):
- ADSORPTION SCREENING TEST
- after 16 hours 35.6 – 53.7% of the test substance adsorb to soil
- moderate adsorption tendency
DESORPTION SCREENING TEST
- 75 -81 % of the adsorbed test substance was desorbed from the soils
MATERIAL BALANCE
- recovered radioactivity ranged from 92.3 -100.7%
TLC-MEASUREMENTS
- Radiolabelled test substance was stable in methanolic solution
- In contact with moist soil the radiolabelled test substance hydrolyzes to acid metabolites
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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