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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of the substance to fish was investigated in 2 studies. In a 96 h acute toxicity study (classified as reliable without restrictions), carp (Cyprinus carpio) were exposed to the substance according to OECD 203 and GLP principles. The 96h-LC50 was 6.8 mg/L, corresponding with 2.6 mg solids/L, based on analytically confirmed nominal concentrations. In a 96 h acute toxicity study, of which the reliability could not be assigned, fish (Salmo salar) were exposed to the substance using a method equivalent/similar to OECD 203 but not under GLP principles. The 96h-LC50 was 2.3 mg/L, which corresponds to 0.9 mg solids/L, based on nominal concentrations (no analytical verification of test concentration).
The LC50 value obtained in the study classified as reliable without restrictions is taken as key value for CSA since it was considered the most reliable.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6.8 mg/L
Additional information
The acute toxicity of the substance to fish was investigated in 2 studies:
Tobor-Kapłon (2013) - In a 96 h acute toxicity study, carp (Cyprinus carpio) were exposed to the substance according to OECD guideline Nr. 203 and GLP principles. Fish were exposed to the following nominal concentrations: 0 (control), 2.2, 4.6, 10, 22 and 46 mg/L, corresponding to 0.85, 1.8, 3.9, 8.5 and 18 mg solids/L.
The substance induced no mortality or other observed effects in carp at 4.6 mg/L, corresponding with 1.8 mg solids/L. The 96h-LC50 was 6.8 mg/L, corresponding with 2.6 mg solids/L based on analytically confirmed nominal concentrations (95% confidence interval between 4.6 and 10 mg/L, corresponding with 1.8 and 3.9 mg solids/L, respectively). The present toxicity study is classified as reliable without restrictions.
Grande (no date) – In a 96 h acute toxicity study, fish (Salmo salar) were exposed to the substance using a method equivalent/similar to OECD 203 but not under GLP principles. Fish were exposed to the following nominal concentrations: 0 (control), 1, 5, 10 and 50 mg/L, corresponding to 0.39, 1.95, 3.9 and 19.5 mg solids/L. The 96h-LC50 was 2.3 mg/L, which corresponds to 0.9 mg solids/L, based on nominal concentrations. The reliability of the study could not be assigned since the used test concentrations were not following the prescribed rules as at least 5 concentrations, arranged in a geometric series with a factor not exceeding 2.2, should have been selected. In addition, no analytical verification of the test concentrations was performed.
Selection of key study
The study conducted by Tobor-Kapłon (2013) was selected as the key study since it was considered the most reliable. The Grande (no date) study used test concentrations which did not followed the prescribed rules as at least 5 concentrations, arranged in a geometric series with a factor not exceeding 2.2, should have been selected. In addition, no analytical verification of the test concentrations was performed.
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