Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 405-800-7 | CAS number: 27955-94-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
For the Ames study and the two of the three in vitro mammalian cell gene mutation tests the results are: negative with metabolic activation; negative without metabolic activation. One in vitro study indicated a positive result with and without activation; chromosome aberration study indicates a positive result with activation at the highest concentration tested due to polyploid cells, although there was no increase in frequency of chromosome aberrations.
Short description of key information:
For the Ames study and the two of the three in vitro mammalian cell gene mutation tests the results are: negative with metabolic activation; negative without metabolic activation. One in vitro study indicated a positive result with and without activation; chromosome aberration study indicates a positive result with activation at the highest concentration tested due to polyploid cells, although there was no increase in frequency of chromosome aberrations.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance does not meet classification criteria under EU Directive 67/548/EEC for genetic toxicity.
The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
