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Diss Factsheets
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EC number: 903-816-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to O.E.C.D. Testing Guideline 403 (Acute Inhalation Toxicity) without GLP compliance.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- The exposure duration was 6 hr, not 4 hr and a full post-treatment observation period of 14 days was not followed.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- As per the IUCLID5 Sections 1.1. - 1.4. for 3-chloropropene.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were acquired from Charles River Breeding Laboratories, Wilmington, Massachusetts, U.S.A. and their age at study initiation was 9-14 wks. The body weight range at study initiation was males: 192 - 284 gm and females: 130 - 166 gm. Upon arrival in the laboratory, rats were housed 5/cage, immediately prior to each exposure, animals were placed in stainless steel exposure cages in groups of either 5 or 10/cage, after exposure, they were placed in their original holding cages in an animal room which was used to house the control groups, until the time of necropsy. The animals were allowed Feed (Purina Rat Chow) and water ad libitum. Their acclimation period was > 7 days. No other conditions were reported.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- The exposure apparatus were glass and stainless steel chambers with a volume 160-liters. A calculated amount of allyl chloride liquid was metered into a heated (approximately 80°C) vaporization flask with a precision syringe pump and sweeping the vapor with filtered air into the main chamber airflow at a rate of approximately 30 liters/minute.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- online monitoring: IR, timed measurements: GC-FID
- Duration of exposure:
- ca. 6 h
- Remarks on duration:
- The O.E.C.D. Testing Guideline recommends 4 hr.
- Concentrations:
- 200, 300, 500, 800, 1000 and 2000 ppm
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Following the exposure period, the frequency of observations and weighing were as follows: pre exposure (day 0), 24 h post exposure (day 1), 48 h post exposure (day 2, 2000 ppm, males only), 72 h post exposure (day 3, 500 and 800 ppm only, both sexes). Full necropsy were performed on survivors. Organ weights for liver and kidneys were taken at necsospy. Clinical chemistry parameters measured were: BUN, SGPT, AP, SGOT and glucose. Histopathology evaluation was performed on samples of liver and kidney.
- Statistics:
- Body weight, clinical chemistry and organ weight data were analyzed statistically using Dunnett's test. The level of significance for all cases was p<0.05.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 1 000 - < 2 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: All females died at 2000 ppm.
- Mortality:
- All females died at the high dose level of 2000 ppm and one male animal died. One female died at 1000 ppm.
- Clinical signs:
- other: Diarrhia and lethargy were observed beginning at a dose level of 500 ppm and became increasing severe as the dose levels increased. Palpebral Closure and conjunctival hyperemia were sever in survivors at the top two dose levels.
- Body weight:
- The body weight of animals exposed to 2000 ppm was substantially reduced.
- Gross pathology:
- The nasal turbinate exhibited nasal discharge at 1000 ppm and at 2000 ppm they were hyperemic and/or edematous. The liver exhibited accentuated lobular pattern with or without associated pale appearance at 1000 and 2000 ppm. The kidneys exhibited pale discoloration of cortex at 300 ppm and 500 ppm, pale cortex with darker medullary junction and generally enlarged or swollen kidneys at 800 ppm and higher. The thymus showed a decreased in size at 1000 ppm and higher. The gastrointestinal tract had decreased contents and depletion of abdominal adipose tissue at 1000 ppm and higher. The testes were edematous at 1000 and 2000 ppm.
Any other information on results incl. tables
For clinical biochemical parameters only the BUN concentration shows a clear dose dependent increase becoming statistically significant at 1000 ppm in males and at 500 ppm in females at 24 h post exposure. The kidneys mean relative weights increased in all tested dose groups from 500 - 2000 ppm, and the absolute weights were raised in the 800 ppm and both 1000 ppm groups. Histopathological examination found kidney acute tubular degeneration at 300 ppm and above in females and at 500 ppm and above in males suggesting the kidney as a potential target organs.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU DSD
- Conclusions:
- Exposure of rats to vapors of 3-chloropeopene for 6 hr resulted in an estimated LC50 of 1000 ppm (3083 mg/m3) to < 2000 ppm (6166 mg/m3) suggesting that inhalation of 3-chloropropene may be Harmful. The kidney was identified as a potential target organ. A similar conclusion could be made for AC Light Ends.
- Executive summary:
The structural analog, 3 -chloropropene was assessed for acute inhalation toxicity in the rat by a study protocol similar to O.E.C.D. Testing Guideline 403 "Acute Inhalation Toxicity". Exposure of rats to vapors of 3-chloropeopene for 6 hr resulted in an estimated LC50 of 1000 ppm (3083 mg/m3) to < 2000 ppm (6166 mg/m3) suggesting that inhalation of 3-chloropropene may be Harmful. The kidney was identified as a potential target organ. A similar conclusion could be made for AC Light Ends.
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