Registration Dossier
Registration Dossier
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EC number: 406-640-0 | CAS number: 136920-07-5 KEROFLUX ES 3241
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Directive XI/681/86/EEC, draft 4
- Principles of method if other than guideline:
- The chronic toxicity of the test substance to Daphnia magna was investigated in a 21 day semistatic test.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration control analysis was conducted by extraction of the test substance with Freon (1,1,2-trifluorotrichloroethane) from the water samples.
- Vehicle:
- no
- Details on test solutions:
- The test was performed with an aqueous extract (eluate) prepared with 10 mg/L. The test substance was reduced to small pieces by means of a mortar, an appropriate amount weighed out and suspended in test medium by stirring for 24 hours. Then, the suspension was filtered.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Age of the animals at the start of the test: 2-24 hours
- Age of stock animals: 2-4 weeks - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Hardness:
- CA 270 mg CaCO3/L
- Test temperature:
- 18.9 - 21.3 °C
- pH:
- 7.7 - 8.2
- Dissolved oxygen:
- 7.7 - 8.9 mg/L
- Nominal and measured concentrations:
- Test concentration (nominal): 10 mg/L
- Details on test conditions:
- - Test vessels: Glass beakers, nominal volume 100 mL
- Test volume: 50 mL
- Number of animals / vessel: 1
- Total number of animals / concentration: 10
- Number of parallels / concentration: 10
- Light: Day/night rhythm 16/8
- Change of test solution: Each Monday, Wednesday and Friday
- Removal of young from beakers and counting: Daily
- Feeding: Daily, according to feeding schedule - Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- other: LC0
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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