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EC number: 201-983-0 | CAS number: 90-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- 96h acute toxicity test
- GLP compliance:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- not specified
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.7 mg/L
- Validity criteria fulfilled:
- not specified
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 96h acute bioassay using rainbow trout as test organism (following recommendations of US-EPA)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: purified PNA (as hydrochloride salt) dissolved in ethanol was added to well-aerated test water, test solutions were vigorously stirred with a glass rod
- Controls: yes, vehicle control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): ethanol
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): not exceeding 0.5 mL/L water (recommended by US EPA) - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: commercial fish hatcheries
- Weight at study initiation (mean and range, SD): 0.6 g
- Feeding during test: no
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): maintained in round fiberglass tanks, flow-through at 13+/-2 °C, 16 h light: 8 h dark
- Type and amount of food: commercial trout feed
- Health during acclimation (any mortality observed): less than 5% mortality observed for more than one year - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 118 mg/L as CaCO3
- Test temperature:
- 13 +/-2 °C
- pH:
- not specified
- Dissolved oxygen:
- not specified
- Nominal and measured concentrations:
- Nominal: 0.13, 0.22, 0.36, 0.60 and 1 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 5 gallon wide-mouth glass jars, containing 15 L of tap water
- Aeration: no data
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 0
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.4 g fish/L test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Syracuse municipal water filtered and dechlorinated through active charcoal
- Total organic carbon: 2.2 +/- 1.7 mg/L
- Particulate matter: < 5 mg/L
- Chlorine: < 10 µg/L
- Alkalinity: 117.9 +/- 10.4 mg/L
- Conductivity: 265+/- 17.3 µmhos/cmL
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light: 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, recorded daily
TEST CONCENTRATIONS
- 0.13, 0.22, 0.36, 0.60 and 1 mg/L
- Spacing factor for test concentrations: at least 0.6
- Range finding study
- Test concentrations: a series of concentrations (dilution factor of at least 0.6) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.44 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated by the moving average method of Thompson when the data permitted (constant dilution factor between the toxicant concentration). Otherwise, the LC50 was estimated by the method of Litchfield and Wilcoxon which requires at least two concentrations producing partial mortalities. If this method could not be used, the LC50 was estimated by graphical interpolation.
- Sublethal observations / clinical signs:
Cumulative mortalities:
0.13 mg/L: 0% after 24, 48 and 96 hours
0.22 mg/L: 0% after 24, 48 and 96 hours
0.36 mg/L: 0% after 24 and 48 hours, 10% after 96 hours
0.60 mg/L: 0% after 24 hours, 100% after 48 and 96 hours
1.00 mg/L: 20% after 24 hours, 70% after 48 hours and 100% after 96 hours
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance showed to be acutely very toxic to rainbow trout in a bioassay screening the acute toxicity (96h) of the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 192h acute bioassay using bluegill sunfish as test organism (following recommendations of US-EPA)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: samples were extracted in a separatory funnel with 20 mL methylene chloride; measured daily
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solution of PNA dissolved in acetone
- Controls: yes
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetone
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): not exceeding 0.5 mL/L water (recommended by US EPA) - Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: Bluegill sunfish
- Source: commercial fish hatcheries
- Weight at study initiation (mean and range, SD): 1.8 g
- Feeding during test: yes, every other day
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): maintained in round fiberglass tanks, flow-through at 20+/-2 °C, 16 h light: 8 h dark
- Type and amount of food: commercial trout feed
- Health during acclimation (any mortality observed): less than 5% mortality observed for more than one year - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 192 h
- Hardness:
- 118 mg/L as CaCO3
- Test temperature:
- 20 +/-2 °C
- pH:
- not specified
- Dissolved oxygen:
- not specified
- Nominal and measured concentrations:
- Nominal: 0.11, 0.18, 0.35 and 0.53 mg/L (Test 1)
Nominal: 0.24, 0.38, 0.64 and 1.05 mg/L (Test 2) - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 30L aquaria
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): 3 L/hour (corresponding to 2.4 tank volumes/day, 90% replacement time of about one day)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 0
- Biomass loading rate: 0.6 g fish/L test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Syracuse municipal water filtered and dechlorinated through active charcoal
- Total organic carbon: 2.2 +/- 1.7 mg/L
- Particulate matter: < 5 mg/L
- Chlorine: < 10 µg/L
- Alkalinity: 117.9 +/- 10.4 mg/L
- Conductivity: 265+/- 17.3 µmhos/cmL
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light: 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, recorded daily
TEST CONCENTRATIONS
- 0.11, 0.18, 0.35 and 0.53 mg/L (nominal) in Test 1
0.24, 0.38, 0.64 and 1.05 mg/L (nominal) in Test 2
- Spacing factor for test concentrations: at least 0.6
- Range finding study
- Test concentrations: a series of concentrations (dilution factor of at least 0.6) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.82 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated by the moving average method of Thompson when the data permitted (constant dilution factor between the toxicant concentration). Otherwise, the LC50 was estimated by the method of Litchfield and Wilcoxon which requires at least two concentrations producing partial mortalities. If this method could not be used, the LC50 was estimated by graphical interpolation.
- Sublethal observations / clinical signs:
Cumulative mortalities:
TEST 1:
0.11 mg/L: 0% after 48, 96, 144 and 192 hours
0.18 mg/L: 0% after 48, 96, 144 and 192 hours
0.35 mg/L: 0% after 48 and 96 hours, 10% after 144 and 192 hours
0.53 mg/L: 0% after 48 and 96 hours, 60% after 144 hours and 90% after 192 hours
TEST 2:
0.24 mg/L: 0% after 48, 96, 144 and 192 hours
0.38 mg/L: 0% after 48, 96 and 144 hours, and 10% after 192 hours
0.64 mg/L: 0% after 48 hours, 10% after 96 hours, 90% after 144 hours and 100% after 192 hours
1.05 mg/L: 40% after 48 hours, 90% after 96 hours, and 100% after 144 and 192 hours
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance showed to be acutely very toxic to bluegill sunfish in a bioassay screening the acute toxicity (192h) of the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 96h acute bioassay using bluegill sunfish as test organism (following recommendations of US-EPA)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: purified PNA (as hydrochloride salt) dissolved in ethanol was added to well-aerated test water, test solutions were vigorously stirred with a glass rod
- Controls: yes, vehicle control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): ethanol
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): not exceeding 0.5 mL/L water (recommended by US EPA) - Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: Bluegill sunfish
- Source: commercial fish hatcheries
- Weight at study initiation (mean and range, SD): 1.0 g
- Feeding during test: no
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): maintained in round fiberglass tanks, flow-through at 20+/-2 °C, 16 h light: 8 h dark
- Type and amount of food: commercial trout feed
- Health during acclimation (any mortality observed): less than 5% mortality observed for more than one year - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 192 h
- Hardness:
- 118 mg/L as CaCO3
- Test temperature:
- 20 +/-2 °C
- pH:
- not specified
- Dissolved oxygen:
- not specified
- Nominal and measured concentrations:
- Nominal: 0.13, 0.22, 0.36, 0.60 and 1 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 5 gallon wide-mouth glass jars, containing 15 L of tap water
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.7 g fish/L test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Syracuse municipal water filtered and dechlorinated through active charcoal
- Total organic carbon: 2.2 +/- 1.7 mg/L
- Particulate matter: < 5 mg/L
- Chlorine: < 10 µg/L
- Alkalinity: 117.9 +/- 10.4 mg/L
- Conductivity: 265+/- 17.3 µmhos/cmL
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light: 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, recorded daily
TEST CONCENTRATIONS
- 0.13, 0.22, 0.36, 0.60 and 1 mg/L
- Spacing factor for test concentrations: at least 0.6
- Range finding study
- Test concentrations: a series of concentrations (dilution factor of at least 0.6) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.82 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated by the moving average method of Thompson when the data permitted (constant dilution factor between the toxicant concentration). Otherwise, the LC50 was estimated by the method of Litchfield and Wilcoxon which requires at least two concentrations producing partial mortalities. If this method could not be used, the LC50 was estimated by graphical interpolation.
- Sublethal observations / clinical signs:
Cumulative mortalities:
0.13 mg/L: 0% after 48, 96, 144 and 192 hours
0.22 mg/L: 11% after 48 hours and 22% after 96, 144 and 192 hours
0.36 mg/L: 30% after 48, 96, 144 and 192 hours
0.60 mg/L: 0% after 48 hours, 10% after 96 hours, 40% after 144 hours and 80% after 192 hours
1.00 mg/L: 0% after 48 hours, 78% after 96 hours and 100% after 144 and 192 hours
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance showed to be acutely very toxic to bluegill sunfish in a bioassay screening the acute toxicity (96h) of the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 192h acute bioassay using rainbow trout as test organism (following recommendations of US-EPA)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: samples were extracted in a separatory funnel with 20 mL methylene chloride; measured daily
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solution of PNA dissolved in acetone
- Controls: yes
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetone
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): not exceeding 0.5 mL/L water (recommended by US EPA) - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: commercial fish hatcheries
- Weight at study initiation (mean and range, SD): 4.4 g
- Feeding during test: yes, every other day
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): maintained in round fiberglass tanks, flow-through at 13+/-2°C, 16 h light: 8 h dark
- Type and amount of food: commercial trout feed
- Health during acclimation (any mortality observed): less than 5% mortality observed for more than one year - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 192 h
- Post exposure observation period:
- no data
- Hardness:
- 118 mg/L as CaCO3
- Test temperature:
- 13 +/-2 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- not relevant
- Nominal and measured concentrations:
- 0.11, 0.24, 0.36 and 0.67 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 30L aquaria
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): 3 L/hour (corresponding to 2.4 tank volumes/day, 90% replacement time of about one day)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 0
- Biomass loading rate: 1.5 g fish/L test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Syracuse municipal water filtered and dechlorinated through active charcoal
- Total organic carbon: 2.2 +/- 1.7 mg/L
- Particulate matter: < 5 mg/L
- Chlorine: < 10 µg/L
- Alkalinity: 117.9 +/- 10.4 mg/L
- Conductivity: 265+/- 17.3 µmhos/cmL
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light: 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, recorded daily
TEST CONCENTRATIONS
- 0.11, 0.24, 0.36 and 0.67 mg/L (nominal)
- Spacing factor for test concentrations: at least 0.6
- Range finding study
- Test concentrations: a series of concentrations (dilution factor of at least 0.6) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.74 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated by the moving average method of Thompson when the data permitted (constant dilution factor between the toxicant concentration). Otherwise, the LC50 was estimated by the method of Litchfield and Wilcoxon which requires at least two concentrations producing partial mortalities. If this method could not be used, the LC50 was estimated by graphical interpolation.
- Sublethal observations / clinical signs:
Cumulative mortalities:
0.11 mg/L: 0% after 48, 96, 144 and 192 hours
0.24 mg/L: 0% after 48 hours and 10% after 96, 144 and 192 hours
0.36 mg/L: 0% after 48 hours, 10% after 96 hours, 70% after 144 hours and 90% after 192 hours
0.67 mg/L: 0% after 48 hours, 60% after 96 hours and 100% after 144 and 192 hours
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance showed to be acutely very toxic to rainbow trout in a bioassay screening the acute toxicity (192h) of the test substance.
Referenceopen allclose all
Description of key information
LC50(96h) = 0.44 mg/L (nominal, vehicle) for Oncorhynchus mykiss (US-EPA method)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.44 mg/L
Additional information
Several studies investigating the short-term toxicity of N-phenyl-1-naphthylamine to fish is availbale. In the key study, the toxicity of the test substance was tested in a semi-static system following US-EPA recommendations using Oncorhynchus mykiss as test organism (Sikka et al. 1981). Nominal concentrations of 0.13, 0.22, 0.36, 0.60 and 1 mg/L were tested, with ethanol as solvent. This study yielded an LC50 value (96h) of 0.44 mg/L. Similar results were obtained in supporting studies, conducted during the same comprehensive investigation with various fish species and test conditions (Sikka et al. 1981). For Lepomis macrochirus, an LC50 value (96h) of 0.82 mg/L was obtained both in a semi-static and flow-through test system, and for Oncorhynchus mykiss, an additional LC50 value (96h) of 0.74 mg/L resulted from exposure in a flow-through test system. In order to be sufficently conservative, the lowest available 96h-LC50 value was used for the chemical safety assessment of the substance. The study obtained in the J-CHECK database of the Japanese Ministry of Environment was not considered for the hazard assessment, since man important information for a proper Klimisch rating is missing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.