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EC number: 220-266-3 | CAS number: 2695-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 June to 7 July 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium 4-vinylbenzenesulphonate
- EC Number:
- 220-266-3
- EC Name:
- Sodium 4-vinylbenzenesulphonate
- Cas Number:
- 2695-37-6
- Molecular formula:
- C8H8O3S.Na
- IUPAC Name:
- .
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Species: SPF bred New Zealand White albino rabbits
Supplier: Charles River Wiga FRG, Sulzfeld, Germany
Sex and age: males, young adult
Date of arrival: June 5, 1992
Body weight range at start of study: 2870-2900 g
Identification: earmarking: 320-322
Acclimatization period: 18 days
Caging: individually in suspended galvanized cages, fitted with wire-mesh floor and front
Lighting: 12 hours light/12 hours dark cycle
Temperature: 20 ± 3 °C
Humidity: 53-87% (upper limit incidentally higher than the intended 70%, because of meteorological circumstances or because of wet cleaning of the
animal room)
Ventilation: ca 10 air changes/hour
Diet: standard laboratory rabbit diet and tap water, ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- A plastic cup with a diameter of ca 2.5 cm was loaded with 0.75 g of the test mixture (0.5 g of the test material and 0.25 g water)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24. 48 and 72 hours, then 7 and 14 days.
- Number of animals:
- 3
- Details on study design:
- After the exposure period, the application site was cleaned with a paper tissue and water
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 7d
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 7d
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 14d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 14d
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- On the basis of the results obtained it was concluded that, under the conditions of this study, the substance is considered severely irritating for the skin of rabbits after a 4-hour dermal contact period.
- Executive summary:
The skin irritation was assessed according to the OECD 404 test guideline in compliance with GLP using three New Zealand White rabbits.
The fur of the application was clipped and the substance applied in water for an expsure period of 4 hours with occluded dressing.
At 24 hours after removal, the skin effects observed in three rabbits consisted of moderate erythema, slight is chemic necrosis, and slight, moderate or severe oedema.
At 48 and 72 hours after removal, the three rabbits showed moderate erythema, very slight or slight ischemic necrosis, and moderate oedema. In addition, one rabbit showed slight incrustation at 72 hours after removal.
At 7 days after removal, well-defined erythema, very slight ischemic necrosis (one rabbit) and very slight oedema were observed in the three rabbits.
At 14 days after removal, all skin effects had cleared completely.
On the basis of the results obtained it was concluded that, under the conditions of this study, the substance is considered severely irritating for the skin of rabbits after a 4-hour dermal contact period.
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