Registration Dossier
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EC number: 802-122-7 | CAS number: 4494-16-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (30 min) > 1000 mg/L for activated sludge (OECD 209)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of octadec-9-enedioic acid (EC 802-22-7) to microorganisms are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance (Z)-9-Octadecen-1,18-dioic acid (CAS 20701-68-2) was conducted. The source substance is representative to evaluate the toxicity of octadec-9-enedioic acid (EC 802-22-7) to microorganisms.
Based on their chemical structure, both the target substance (Octadec-9-enedioic acid, EC 802-22-7) and the source substance ((Z)-9-Octadecen-1,18-dioic acid, CAS 20701-68-2), belong to the family of linear monounsaturated dicarboxylic acids. While the target substance contains a cis- and trans-isomer, the source substance consists of the cis-isomer.
This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
A GLP study according to OECD guideline 209 with activated sludge was performed with the analogue substance (Z)-9-Octadecen-1,18-dioic acid (CAS 20701-68-2), the cis-isomer of both of the stereo-isomers, under static conditions (Desmares-Koopmans, 2001). Activated sludge was exposed to the test item at nominal concentrations of 46, 100, 220, 600, 1000 mg/L, and an untreated control. Before weighing the test substance was melted at 80 °C in a waterbath. The test substance was hardly soluble in water and was added quantitatively to the test vessels.Exposure of activated sludge bacteria to test item concentrations ranging from approximately 46 to 600 mg/L resulted in no significant inhibition in respiration rate of the sludge. At the highest concentration tested, approximately 1000 mg/L, 18% inhibition in respiration rate of the sludge was recorded. However, it should be noted that the linear part of the respiration curve of this concentration was relative small (a few minutes). Based on this result it was concluded that the EC50 is >1000 mg/L.
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