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EC number: 267-032-7 | CAS number: 67762-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- substance was tested above the limit dose; missing data on animals
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, phosphosulfurized
- EC Number:
- 267-032-7
- EC Name:
- Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, phosphosulfurized
- Cas Number:
- 67762-73-6
- IUPAC Name:
- Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, phosphosulfurized
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): EC 267-032-7
- Physical state: a viscous, pale yellow liquid with an unpleasant odor
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data present beyond the species, strain and that both sexes were used
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped abraded abdominal skin
- Type of wrap if used: binders of rubber dam, gauze and adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cleansed with corn oil
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50, 200, 794, 3160 mg/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 50, 200, 794, 3160 mg/kg bw
- No. of animals per sex per dose:
- 4 animals per dosage level. No data showing the number of sexes in each group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals observed at 1, 4 and 24 hours and then daily. Observations were for mortality and toxic effects.
- Necropsy of survivors performed: yes - Statistics:
- None
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths observed at any dosage level
- Mortality:
- None
- Clinical signs:
- other: All animals showed slight or moderate erythema that never lasted beyond day 9. Desquamation noted at the 2 highest concentrations and edema and atonia observed in the highest. Severity and duration showed a dose response effect (see results table)
- Gross pathology:
- None observed
Any other information on results incl. tables
Signs of dermal irritation observed in male and female albino rabbits.
Observation interval (days) | 50 mg/kg | 200 mg/kg | 794 mg/kg | 3,160 mg/kg | ||||
Erythema | Erythema | Erythema | Desquamation | Erythema | Edema | Atonia | Desquamation | |
1 | +(4) | +(4) | +(3) ++(1) | - | +(2)++(2) | +(2) | - | - |
2 | - | +(1) | +(4) | - | +(2)++(2) | +(2) | - | - |
3 | - | - | +(4) | - | +(4) | - | +(1) | - |
4 | - | - | - | +(4) | +(3) | - | - | +(2) |
5 | - | - | - | +(3) | +(2) | - | - | +(2) |
6 | - | - | - | +(3) | +(1) | - | - | +(2) |
7 | - | - | - | +(3) | - | - | - | +(3) |
8 | - | - | - | +(1) | - | - | - | +(3) |
9 | - | - | - | - | - | - | - | +(1) |
+ = slight
++ = moderate
+++ = severe
(x) = number of animals showing that effect
- = no toxicity observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for the test substance dermal exposure to rabbits is assumed to be >3160 mg/kg bw as no mortality was observed ar any of the tested concentrations. The test substance did not meet the criteria for classification according to Regulation (EC) No.1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures.
- Executive summary:
Following a protocol equivalent to OECD guideline 402, New Zealand white rabbits were exposed dermally to the test substance. Four rabbits were tested at each of the four concentrations. Some slight to moderate clinical effects were observed following a dose dependent pattern, but had all disappeared before the end of the observation period. No mortality was observed at any of the concentrations indicating the LD50 for dermal exposure to the registered substance is greater than 3160 mg/kg bw. No gross alterations were observed after necropsy of the animals. The registered substance did not meet the criteria for classification according to Regulation (EC) No.1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures.
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