Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-763-0 | CAS number: 72676-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment (Version 3.0 June 2017) a PBT assessment must take into account the PBT/vPvB properties of relevant constituents and relevant transformation and/or degradation products. Although 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione undergoes non-hydrolytic transformation when exposed to a protic solvent, the transformation is more accurately described as tautomerization. Tautomers are considered to be the same compound of the parent substance; therefore, PBT Assessments of each tautomer would not be appropriate. Nevertheless a screening PBT assessment was conducted with each of the degradation products, identified by the EAWAG tool, with the US EPA EPISUITE software. None of the identified degradation products are bioaccumulable according to Biowin estimations.
Persistence (P)
In an OECD Guideline 301B study, conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione achieved 0% biodegradation after 28 days and is therefore considered as not readily biodegradable (Harlan Laboratories, Ltd, 2016).
According to Table R.11-4 of ECHA’s guidance on information requirements and chemical safety assessment chapter R11 (v3.0, June 2017, p.49), 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should be considered as potentially P or vP.
In addition, 12 of the 18 degradation products identified by the EAWAG tool are not expected to be persistent.
Bioaccumulation (B)
In a study conducted according to GLP, the partition coefficient (log Pow) of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione estimated based on the ratio of n-octanol solubility and water solubility is 1.46 at 25 ± 1°C (Intertek Pharmaceutical Services Manchester, 2016).
According to Figure R.11-4 of ECHA’s guidance on information requirements and chemical safety assessment chapter R11 (v3.0, June 2017, p.68), 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should be considered as not B and not vB.
In addition, none of the 18 degradation products identified by the EAWAG tool are expected to bioaccumulate.
Toxic (T)
As the substance does not meet the B/vB criteria, no assessment is needed on the T criterion and the substance is not considered PBT or vPvB,
Overall Summary:
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment (Version 3.0 June 2017) 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should not be considered as PBT or vPvB, nor its identified degradation products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.