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EC number: 256-851-5 | CAS number: 50925-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-08-23 to 1988-02-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: national standard method
- GLP compliance:
- no
- Radiolabelling:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Length at study initiation (length definition, mean, range and SD): 9.7 cm
- Weight at study initiation (mean and range, SD): 25.2 g
- Lipid content at test initiation (mean and range, SD): 5 % - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Hardness:
- no data
- Test temperature:
- 25 °C +/- 1 °C
- Dissolved oxygen:
- 6.5 - 7.0 mg/L (2 mg/l test substance), 6.2 - 6.9 (0.2 mg/L test substance)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100L, made of glass
- Flow rate: 582 L/day
- Dilution water: 4 ml/min; 400 ml/min
- Concentration stock solution: 200 ppm (w/v), 20 ppm (w/v)
- No. of vessels per concentration (replicates): 2
- External desinfection: 10 mg/L chlorotetracycline hydrochloride in an aquarius solution for 24 hours
RANGE-FINDING / PRELIMINARY STUDY
- Results used to determine the conditions for the definitive study: > 1000 mg/L
- 48 h (Oryzias latipes) - Nominal and measured concentrations:
- 0.2 and 2 mg/L
- Reference substance (positive control):
- not specified
- Lipid content:
- 5 %
- Conc. / dose:
- 2 mg/L
- Type:
- BCF
- Value:
- > 0.6 - < 1.8 L/kg
- Conc. / dose:
- 0.2 mg/L
- Type:
- BCF
- Value:
- < 5.5 L/kg
- Details on results:
- - Behavioural abnormalities: no abnormalities observed
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The BCF was 0.6 - 1.8 L/kg at 2 mg/L of Direct Yellow 86.
- Executive summary:
According to a national standard method a bioaccumulation study was performed. Fish (cyprinus caprio) were kept in the continuous flow-through bioconcentration test system comprised of two sets of test substance level (0.2 and 2 mg/L) for 6 weeks. During the exposure period, the concentrations of the test substance in the test water and fish were measured periodically, and their ratios were used to calculate the bioconcentration factors (BCF) to evaluate bioconcentration potential of the test substance in fish. A range finding test was performed with the test fish Oryzias latipes for 48 hours with the result > 1000 mg/L. In the BCF study body weight and body length was measured. The length of the fish was 9.7 cm, the weight 25.2 g and the lipid content 5 %. The 100 L glas test vessel has a flow rate of 582 L/day. An external desinfection with 10 mg/L chlorotetracycline hydrochloride in an aquarius solution was made for 24 hours. The test temperature was 25 °C +/- 1 °C.
At end of the test no abnormalities were observed. The BCF was 0.6 - 1.8 L/kg at 2 mg/L and < 5.5 L/kg at 0.2 mg/L test substance.
Reference
Description of key information
The BCF was 0.6 - 1.8 L/kg at 2 mg/L of Direct Yellow 86.
Key value for chemical safety assessment
- BCF (aquatic species):
- 1.8 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.