Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-074-5 | CAS number: 431-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
Using prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be1287.5 mg/lfor Methyl trifluoroacetate in 96 hrs.
Short-term toxicity to aquatic invertebrates
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for Methyl trifluoroacetate (CAS no.431-47-0). Effect concentration i.e EC50 value was estimated to be 274.62 mg/l for Daphnia magna for 48 hrs duration.
Toxicity to aquatic algae and cyanobacteria
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substanceMethyl trifluoroacetate(CAS no.431-47-0). EC50 value was estimated to be 210.41 mg/l for Desmodesmus subspicatus for 72 h duration. Based on this value it can be concluded that the substanceMethyl trifluoroacetate(CAS no.431-47-0) is likely to be non toxic to aquatic environment and can be considered to be not classified as per the CLP classification criteria.
Additional information
Short-term toxicity to fish
Two studies including predicted data from validated tools and authorative database for short term fish endpoint of test chemicalMethyl trifluoroacetate(Cas no. 431 -47 -0) log Kow as primary descriptor were summarised as follows:
Using prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be1287.5 mg/lfor Methyl trifluoroacetate in 96 hrs.
According to aquatic toxicity module i.e ACD/LabsI-Lab 2.0; Algorithm Version: v5.0.0.184 the lethal concentration (LC50) of Methyl trifluoroacetate was predicted to be 720 mg/l on fish species Fathead minnow (Pimephales promelas).
The Reliability Index (RI) of the prediction was reported to be 0.51(As per model substance have moderate and high reliability if RI > 0.5). Thus reported RII value indicates it has moderate reliability.
Thus based on the all available effect concentrations which is in the range of 720 mg/l to 1287 mg/l for target and read across chemicals which come to the conclusion that test substance Methyl trifluoroacetate (Cas no. 431-47-0) was likely to be non-toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.
Short-term toxicity to aquatic invertebrates
Four studies including predicted data from validated tools and experimental data from peer reviewed journal and authorative database for short term aquatic invertebrate’s endpoint of test chemicalMethyl trifluoroacetate (CAS no.431-47-0)with relevant read across which is close to target
using log Kow as primary descriptor were summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for Methyl trifluoroacetate (CAS no.431-47-0). Effect concentration i.e EC50 value was estimated to be 274.62 mg/l for Daphnia magna for 48 hrs duration.
Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be653 mg/Lfor fish for 96 hr.
Short-term toxicity test was carried out to study the effects Isopentyl lactate on aquatic invertebrates under static condition. Effective concentration at which the organisms found to be immobile was measured.Effective concentration to 50% of Daphnia magna for Isopentyl lactate is 320 mg/L. On the basis of which it can be concluded that the Isopentyl lactate is not toxic to aquatic invertebrates. And can be considered to be “not classified” under CLP regulation
Another read acrossIsopentyl lactate(CAS no. 19329-89-6) the experimental result from peer reviewed journalChemosphere1998 which suggest theShort-term toxicity test was carried out to study the effects Butyl lactate on aquatic invertebrates under static condition. Effective concentration at which the organisms found to be immobile was measured.Effective concentration to 50% of Daphnia magna for Isopentyl lactate is 193 mg/L.
Thus based on the all available effect concentrations which is in the range of 193 mg/l to 653 mg/l for target and read across chemicals which come to the conclusion that test substance Methyl trifluoroacetate (CAS no.431-47-0) was likely to be non-toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.
Toxicity to aquatic algae and cyanobacteria
Four studies including predicted data from validated tools and experimental data from secondary source
for toxicity to aquatic algae endpoint of test chemical Methyl trifluoroacetate(CAS no.431-47-0) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance Methyl trifluoroacetate(CAS no.431-47-0). EC50 value was estimated to be 210.41 mg/l for Desmodesmus subspicatus for 72 h duration.
Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest on the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 306.67 mg/l for green algae for 96 h duration.
The above predicted results for target assisted by experimental data of read across chemicalButyl lactate(CAS no: 138-22-7)frompeer reviewed journalChemosphere 1998the effect concentration (EC50) of substanceButyl lactate(CAS no: 138-22-7)in test speciesPseudokirchneriella subcapitatawas observed to be 375 mg/l on the basis of Growth Rate effect for 72 hrs exposure period.
Another experimental data of read across chemicalIsopentyl lactate(CAS no: 19329-89-6)frompeer reviewed journalChemosphere 1998,Toxicity to aquatic algae and cyanobacteria test was carried out to study the effects of Isopentyl lactate on Pseudokirchneriella subcapitata under static conditions. Effective concentration to 50% of Pseudokirchneriella subcapitata is 320 mg/L considering decreasing Population growth rate.
Thus based on the effect concentrations which is in the range 210.41 mg/l to 375 mg/l give the conclusion that test substanceMethyl trifluoroacetate (CAS no.431-47-0)was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.