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EC number: 215-656-5 | CAS number: 1337-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test material Undecanal is likely to be non toxic upon repeated exposure.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- No data
- Remarks:
- Doses / Concentrations:
No data
Basis: - No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Positive control:
- No data
- Observations and examinations performed and frequency:
- No data
- Sacrifice and pathology:
- No data
- Other examinations:
- No data
- Statistics:
- No data
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- No data
- Dose descriptor:
- NOAEL
- Effect level:
- 680 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- food consumption and compound intake
- Critical effects observed:
- not specified
- Conclusions:
- The No Observed Adverse Effect Level (NOAEL) for the test compound Undecanal (CAS no 1337-83-3) is found to be 680 mg/Kg bw (actual dose ingested) using male/female rats.
- Executive summary:
Repeated dose oral toxicity study was performed for the test compound undecanal using rats by the gavage route of exposure. The No Observed Adverse Effect Level (NOAEL) for the test compound 4-aminoazobenzene-3,4'-disulphonic acid is found to be 680 mg/Kg bw (actual dose ingested) using rats.
Reference
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and "i" )
and ("j"
and "k" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aldehydes (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Alkene AND Allyl AND Alpha,beta
unsaturated aldehyde by Organic Functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Allyl AND Alpha,beta unsaturated
aldehyde AND Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Carbonyl,
olefinic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or oxide (=O)
AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Michael addition AND Michael
addition >> Polarised Alkenes AND Michael addition >> Polarised Alkenes
>> Polarised alkene - aldehydes AND Schiff Base Formers AND Schiff Base
Formers >> Direct Acting Schiff Base Formers AND Schiff Base Formers >>
Direct Acting Schiff Base Formers >> Mono-carbonyls by Protein binding
by OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation
Involving a Leaving group >> Acyl halides (including benzyl and
carbamoyl deriv.) OR Acylation >> Direct Acylation Involving a Leaving
group >> Anhydrides OR Acylation >> Direct Acylation Involving a Leaving
group >> Azlactone OR Acylation >> Direct Acylation Involving a Leaving
group >> Sulphonyl halides OR Acylation >> Isocyanates and Related
Chemicals OR Acylation >> Isocyanates and Related Chemicals >>
Isocyanates OR Acylation >> Isocyanates and Related Chemicals >>
Thiocyanates-Acylation OR Acylation >> Ring Opening Acylation OR
Acylation >> Ring Opening Acylation >> alpha-Lactams OR Michael addition
>> Acid imides OR Michael addition >> Acid imides >> Acid imides-MA OR
Michael addition >> Polarised Alkenes >> Polarised alkene - amides OR
Michael addition >> Polarised Alkenes >> Polarised alkene - cyano OR
Michael addition >> Polarised Alkenes >> Polarised alkene - esters OR
Michael addition >> Polarised Alkenes >> Polarised alkene - ketones OR
Michael addition >> Polarised Alkenes >> Polarised alkene - nitro OR
Michael addition >> Polarised Alkenes >> Polarised alkene - pyridines OR
Michael addition >> Polarised Alkynes OR Michael addition >> Polarised
Alkynes >> Polarised alkyne - aldehyde OR Michael addition >> Polarised
Alkynes >> Polarised alkyne - pyridine OR Michael addition >> Quinones
and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Benzoquinones OR Michael addition >> Quinones
and Quinone-type Chemicals >> Pyranones (and related nitrogen chemicals)
OR Michael addition >> Quinones and Quinone-type Chemicals >>
Quinone-diimine OR Michael addition >> Quinones and Quinone-type
Chemicals >> Quinone-imine OR Michael addition >> Quinones and
Quinone-type Chemicals >> Quinone-methides OR No alert found OR Schiff
Base Formers >> Direct Acting Schiff Base Formers >> 1-2-Dicarbonyls OR
Schiff Base Formers >> Direct Acting Schiff Base Formers >>
1-3-Dicarbonyls OR Schiff Base Formers >> Direct Acting Schiff Base
Formers >> Di-substituted alpha, beta-unsaturated aldehydes OR SN2 OR
SN2 >> Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation
>> 1,2-Dihaloalkane OR SN2 >> Episulfonium Ion Formation >> Mustards OR
SN2 >> Epoxides and Related Chemicals OR SN2 >> Epoxides and Related
Chemicals >> Aziridines OR SN2 >> Epoxides and Related Chemicals >>
Epoxides OR SN2 >> SN2 reaction at a halo atom OR SN2 >> SN2 reaction at
a halo atom >> N-haloimides OR SN2 >> SN2 reaction at a nitrogen atom OR
SN2 >> SN2 reaction at a nitrogen atom >> N-Acetoxy-N-acetyl-phenyl OR
SN2 >> SN2 reaction at a nitrogen atom >> N-Acyloxy-N-alkoxyamides OR
SN2 >> SN2 reaction at a nitrogen atom >> Nitrosoureas (nitrogen) OR SN2
>> SN2 reaction at a sp2 carbon atom OR SN2 >> SN2 reaction at a sp2
carbon atom >> Polarised alkenes with a halogen leaving group OR SN2 >>
SN2 reaction at a sp2 carbon atom >> Polarised alkenes with a phosphate
leaving group OR SN2 >> SN2 reaction at a sp2 carbon atom >> Polarised
alkenes with a tiophosphate leaving group OR SN2 >> SN2 reaction at a
sulphur atom OR SN2 >> SN2 reaction at a sulphur atom >> Disulfides OR
SN2 >> SN2 reaction at a sulphur atom >> Isothiazol-3-ones (sulphur) OR
SN2 >> SN2 reaction at a sulphur atom >> Thiocyanates-SN2 OR SN2 >> SN2
reaction at a sulphur atom >> Thiols OR SN2 >> SN2 reaction at sp3
carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl diazo OR
SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl halides OR SN2 >> SN2
reaction at sp3 carbon atom >> Allyl acetates and related chemicals OR
SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halo ethers OR SN2 >>
SN2 reaction at sp3 carbon atom >> alpha-Haloalkenes (and related cyano,
sulfate and sulfonate subs. chem.) OR SN2 >> SN2 reaction at sp3 carbon
atom >> alpha-Halobenzyls (and related cyano, sulfate and sulphonate
subs. chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >>
alpha-Halocarbonyls OR SN2 >> SN2 reaction at sp3 carbon atom >>
beta-Halo ethers OR SN2 >> SN2 reaction at sp3 carbon atom >>
Nitrosoureas (carbon) OR SN2 >> SN2 reaction at sp3 carbon atom >>
Phosphates OR SN2 >> SN2 reaction at sp3 carbon atom >> Phosphonates OR
SN2 >> SN2 reaction at sp3 carbon atom >> Sulfonates OR SN2 >> SN2
reaction at sp3 carbon atom >> Thiophosphates OR SNAr OR SNAr >>
Nucleophilic aromatic substitution OR SNAr >> Nucleophilic aromatic
substitution >> Activated halo-benzenes OR SNAr >> Nucleophilic aromatic
substitution >> Activated halo-pyridines OR SNAr >> Nucleophilic
aromatic substitution >> Halo-pyrimidines OR SNAr >> Nucleophilic
aromatic substitution >> Halo-triazines by Protein binding by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Non binder, non cyclic structure
by Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "i"
Similarity
boundary:Target:
CCCCCCCCC=CC=O
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "j"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.27
Domain
logical expression index: "k"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 5.24
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 680 mg/kg bw/day
- Species:
- rat
- Quality of whole database:
- Data is obtained from K2 prediction model
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated dose toxicity: Oral
Repeated dose oral toxicity study was performed for the test compound undecanal (CAS no 1337-83-3) using rats by the gavage route of exposure.
The No Observed Adverse Effect Level (NOAEL) for the test compound 4-aminoazobenzene-3,4'-disulphonic acid is found to be 680 mg/Kg bw (actual dose ingested) using rats.
In a sub-acute repeated dose oral toxicity study by Sustainability Support Services (Europe) AB (2015), male and female Wistar rats were treated with Aldehyde C-11 Undecylenic (RA CAS no 112-45-8) in the concentration of 250, 500 or 1000 mg/kg body weight/day by gavage. No effects were observed on survival and clinical sign of treated rats. Statistically significant variations in the number of rears were observed during pre-treatment in male at week 2 and female at week 3, but the observed effect were not regarded to be treatment-related. No statistically significant changes in bodyweight and weight gain, food consumption or ophthalmological changes were observed in treated rats. Hematologic results showed a statistically significant decrease in MCV and MCH in males, and in RBC, hemoglobin, hematocrit, prothrombin time (PT) in female at 1000 mg/kg bw/day in recovery period. However, the observed changes were considered to be of no toxicological significance since changes were observed in only one sex, of a minimal in nature. Statistically significant decrease in pH and urine volume were seen at 250 mg/kg bw/day, as well as a decrease in pH and urine volume and increased in specific gravity at 500 mg/kg bw/day. A decrease in pH at 1000 mg/kg bw/day in male rats were also observed. The altered parameters were reversed to normal level during treatment free recovery period. No gross external and internal gross pathological changes were observed in all treated rats. Focal minimal to multifocal mild mononuclear cell infiltration in lungs and trachea were observed in male and female rats, and diffuse minimal lympho-phagocytosis in thymus of female rats at 1000 mg/kg bw/day. Therefore, NOAEL was considered to be 1000 mg/kg body weight/day when Wistar male and female Rats were treated with Aldehyde C-11 Undecylenic for 28 days.
In a Combined repeated dose repro-devp. Screen (General Foundation Food and Drug Safety Center, 2014), Sprague-Dawley (SD) (Crl: CD (SD), SPF) male and female rats treated with Undecanal (RA CAS no 112-44-7) in the concentration of 0, 100, 300 and 1000 mg/kg/day in corn oil. One female satellite and recovery group is also maintained at 1000 mg/kg/day. No effect on clinical sign and general condition, Body weight and weight gain were observed in treated, satellite and recovery group as compared to control. Significant increase in food consumption of female rats was observed at 300 and 1000 mg/kg/day as compared to control. Significant decrease in APTT level of female rats at 100 and 1000 mg/kg/day in treated group and significant decrease in eosinophil level of female rats in recovery were observed as compared to control. Significant increase in Cl level of male and female rats at 1000 mg/kg/day and decrease in ALT level of female rats at 300 mg/kg/day in treatment group and significant increase in ALT level of female rats in satellite group were observed at 1000 mg/kg/day as compared to control. No significant effect was observed in urine analysis of treated rats as compared to control. Significant increase in hind limb grip strength at 100, 300 and 1000 mg/kg/day, significant increase in ambulation at 15 min in motor activity in treatment and ambulation and rearing at 15 min in motor activity in satellite group were observed in treated female rats as compared to control. Similarly, significant increase in absolute and relative spleen and relative adrenal weight were observed in female rats of satellite group as compared to control. Nodule in epididymis, unilateral kidney, and partial adhesion with diaphragm in liver and alopecia on skin in male rats and diverticulum ileum, dark colored spot on lung, unilateral cyst in ovary, enlargement of spleen and dark colored area in stomach in female rats were observed in 100, 300 and 1000 mg/kg/day dose group as compared to control. All the changes are considered to be non-graded. In addition, Very slight Degeneration/fibrosis of heart , accumulation, foam cell alveolus in lung, fatty change, hepatocyte, periportal liver, deposit, pigment, brown spleen, basophilic tubule in kidney and cellular infiltration in prostate and follicular cyst in ovary of 1000 mg/kg/day treated male and female rats were observed as compared to control. Therefore, NOAEL was considered to be 1000 mg/kg/day for male rats and 300 mg/kg/day for female rats when Sprague-Dawley (SD) (Crl: CD (SD), SPF) male and female rats treated with Undecanal orally by gavage for 42 days.
In a toxicological study by Oser et al (1965), male and female FDRL rats were fed diet containing 0 or 10.6 mg/kg/daya-ionone (RA CAS no 121-41-3), a concentration that was reported by conducted measurement to provide an average intake of 11.8 mg/kg/day for males and 11.1 mg/kg/day for females for 90 days. No exposure-related effects were observed based on evaluations of body weight, food intake, hematology, blood chemistry, liver and kidney weights and histopathology. Therefore, NOAEL for male FDRL rats was considered to be 11.8 mg/kg/day while NOAEL for female FDRL rats was considered to be 11.1 mg/kg/day when exposed to alpha -ionone.
Based on the weight of evidence data available, the test material Undecanal is likely to be non toxic upon repeated exposure.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The No Observed Adverse Effect Level (NOAEL) for the test compound 4-aminoazobenzene-3,4'-disulphonic acid is found to be 680 mg/Kg bw (actual dose ingested) using rats.
Justification for classification or non-classification
Based on the weight of evidence data, the test material Undecanal is likely to be non toxic upon repeated exposure and hence can be 'not classified' for toxicity upon repeated exposure.
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