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EC number: 242-828-7 | CAS number: 19125-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is expected to be not readily biodegradable.
Biodegradation in water and sediment:
Estimated half life of test
chemical 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
in water was 15 days (360 h) and in sediment estimated to be 135 days
(3240 h).
Biodegradation in soil:
Biodegradation half-life of test
substance 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
in soil was estimated to be 30 days (720 hrs).
Additional information
Biodegradation in water:
Predicted data for the substance 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione and the experimental data of its read across substances were reviewed for the endpoint Biodegradation in water and are summarized below as weight of evidence approach:
Estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione (CAS no. 19125 -99 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is expected to be not readily biodegradable.
The biodegradation of 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione was estimated using QSAR prediction models. Prediction was done using QSAR Toolbox version 3.4. According to the quantitative structure activity relationship(QSAR) model prediction, the substance 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione shows 6.80% degradation in 28 days. Thus it was concluded that the test compound is not readily biodegradable in water.
28 days test was carried out for the read across substance 5,5-diphenylimidazolidine-2,4-dione [synonym:phenytoin; CAS No. 57-41-0] to determine its biodegradability in water (J-check database, 2017). The concentration of the substance used was 100 mg/L and the concentration of sludge was 30 mg/L. After 28 days 1% degradation was found following BOD parameter while 2% degradation was found following HPLC parameter. These values indicates that the substance 5,5-diphenylimidazolidine-2,4-dione [synonym:phenytoin] is not readily biodegradable in water.
14 days test was carried out for other structurally similar substance N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide); CAS No. 91-96-3; to determine its biodegradability in water (Finnish Environment database, 2017). The concentration of the substance used was 100 mg/L and the concentration of sludge was 30 mg/L. After 14 days 0% degradation was found following BOD parameter. This value indicates that the substance N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide) is not readily biodegradable in water.
Considering above results and by applying weight of evidence approach it can be concluded that the substance 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is expected to be not readily biodegradable.
Biodegradation in water and sediment:
Estimation Programs Interface
(EPI Suite, 2017) prediction model was run to predict the half-life in
water and sediment for the test compound 2 -butyl-6
-(butylamino)-1H-benzo[de]iso quinoline-1,3(2H)-dione (CAS No.19125 -99
-6). If released in to the environment, 18.5% of the chemical will
partition into water according to the Mackay fugacity model level III
and the half-life period of
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione in water
is estimated to be 15 days (360 hrs). The half-life (15 days estimated
by EPI suite) indicates that the chemical is not persistent in water and
the exposure risk to aquatic animals is moderate to low whereas the
half-life period of 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3
(2H)-dione in sediment is estimated to be 135 days (3240 hrs). However,
as the percentage release of test chemical into the sediment is less
than 1% (i.e, reported as 0.73%), indicates that
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is not
persistent in sediment.
Biodegradation in soil:
The half-life period of
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione (CAS No.
19125 -99 -6) in soil was estimated using Level III Fugacity Model by
EPI Suite version 4.1 estimation database (EPI suite, 2017). If released
into the environment, 80.7% of the chemical will partition into soil
according to the Mackay fugacity model level III. The half-life period
of 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione in soil
is estimated to be 30 days ( 720 hrs). Based on this half-life value of
2 -butyl-6 -(butylamino)-1H-benzo[de]iso quinoline-1,3(2H)-dione, it is
concluded that the chemical is not persistent in the soil environment
and the exposure risk to soil dwelling animals is moderate to low.
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