Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: English summary of a Russian non-guideline study. No or very limited information on design and methods of the study.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Pathomorphology of the central nervous system during the chronic poisoning of rats with α-picoline
- Author:
- Polilei, S.A.
- Year:
- 1 969
- Bibliographic source:
- Tr.Krasnoyarsk Gos. Med. Inst. 9(1), 80-85, 1969 (Russ) cited in Chem.Abstr, Vol 75
Materials and methods
- Principles of method if other than guideline:
- The test substance was given orally for 6 month to rats. After the exposure period, animals were decapitated. Brain and spinal cord were examined histopathologically.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): α-picoline
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 6 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.0025, 0.01 or 0.05 mg/kg bw
Basis:
no data
- Control animals:
- no
Examinations
- Sacrifice and pathology:
- Brain and spinal cord were examined histopathologically
Results and discussion
Results of examinations
- Details on results:
- - Functional and dystrophic changes in cells of the 1st, 2nd, 3rd, and 5th layer of the cerebral cortex, but also of the sub-cortex were observed. At the dose of 0.0025 mg/kg bw these changes were mostly functional but single neurons of the thalamo-hypothalamnic region showed swelling, chromatolysis, wrinkling, and hyperchromatosis.
- By raising the dose of the test substance, dystrophic changes in all parts of the brain increase, and become most pronounced in the 3rd group of rats.
- Chronic intoxication of animals with the test substance is accompanied by vascular disturbances aggravating neuronal and glial lesions. Chronically intoxicated rats of the 3rd group showed a relatively constant demyelination of nerve pathways in the brain.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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