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Diss Factsheets
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EC number: 201-377-6 | CAS number: 81-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information about study methodology, animals, and results.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicity of 3-(Acetonylbenzyl)-4-Hydroxycoumarin (Warfarin) to Laboratory Animals
- Author:
- Hagan EC, Radomski JL
- Year:
- 1 953
- Bibliographic source:
- Journal of the American Pharmaceutical Association XLII(6), 379-382
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The lethal dose of warfarin to a number of different animal receptors was evaluated.
- Test type:
- other: acute and subacute toxicity, methodology not outlined
Test material
- Reference substance name:
- Warfarin
- EC Number:
- 201-377-6
- EC Name:
- Warfarin
- Cas Number:
- 81-81-2
- Molecular formula:
- C19H16O4
- IUPAC Name:
- 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
- Reference substance name:
- 3(acetonybenzyl)-4-hydroxycoumarin
- IUPAC Name:
- 3(acetonybenzyl)-4-hydroxycoumarin
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Food and water ad libitum.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on oral exposure:
- Added to food.
- Doses:
- 1, 3, 6.25, 12.5, 25, 50, 100, and 250 ppm.
- No. of animals per sex per dose:
- 4-6 animals per dose group (equal number of each sex.)
- Control animals:
- no
Results and discussion
Effect levels
- Remarks on result:
- other: 250 and 50 ppm warfarin were found more toxic to rats than 10 ppm when fed for periods from one to five days. However, levels of 10 ppm are as toxic when fed for longer periods.
- Clinical signs:
- other: Symptoms and gross autopsy findings from acute doses were variable depending on the time of death. Convulsions were observed in animals which succumbed within several hours after receiving the very highest doses by stomach tube. In animals dying delayed
Applicant's summary and conclusion
- Conclusions:
- 250 and 50 ppm warfarin were found more toxic to rats than 10 ppm when fed for periods from one to five days. However, levels in the neighborhood of 10 ppm are as toxic as 250 and 50 ppm when fed for longer periods.
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