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Diss Factsheets
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EC number: 204-593-9 | CAS number: 123-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The key study for degradation in water screening tests was a closed bottle ready biodegradability test conducted on the test substance, which showed that the substance was not readily biodegradable. The results of another closed bottle test from a supporting study found in the published literature reported 25% biodegradation of the substance in 28 days, indicating inherent biodegradability. Although ready biodegradability was not shown in the key study for biodegradation in water screening tests, an aerobic soil simulation study was undertaken (summarised as the key study in Section 5.2.3 of this IUCLID file). The aerobic soil simulation study reported 70.7% in 28 days; these results showed that the substance was rapidly biodegradable, but did not show that the 10-day window was achieved.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
The substance was not shown to be readily biodegradable in a closed bottle test conducted in accordance with GLP; 0% degradation was observed at 28 days at a test substance concentration of 2 mg/L, below the threshold of 60% degradation for ready biodegradability. However, the findings of a supporting study from the published literature reported 25% degradation at 28 days at a test concentration of 1 mg/L in a closed bottle test, below the threshold of 60% degradation for ready biodegradability, but indicative of inherent biodegradability. An aerobic soil simulation biodegradation study showed that the substance was rapidly biodegradable in soil under aerobic conditions; the soils were not pre-adapted to the substance, which was applied at a concentration of 0.376 mg/kg soil dry weight. The soil simulation study reported mineralisation of 1.2%, 14.7%, 31.1%, 49.1%, 63.5% and 70.7% in three, seven, 10, 14, 21 and 28 days; the results at these intervals showed that the substance was rapidly biodegradable, but did not show that the 10-day window was achieved.The DT50 for the substance (i.e., the parent compound) and its primary metabolite (i.e., Metabolite II) were reported as 9.7 days and 3.5 days, respectively, each based on the Single First Order Model. Therefore, the substance has been shown to be rapidly biodegradable under aerobic conditions. The experimentally-determined rapid degradation in soil is sufficient documentation for showing rapid degradation in surface water and sediment, in accordance with ECHA guidance (Guidance on the application of the CLP criteria, Version 3.0, November 2012, Section II.2.3.6, p. 498).
The potential for respiratory inhibition by the test substance was also evaluated in the key study for biodegradation in water screening tests. Although possible inhibition of respiratory activity was indicated when oxygen concentrations of the blank controls were compared to those of the test substance vessels, the substance was not found to meet the criteria for classification as inhibitory, based on toxicity controls at a test substance concentration of 2 mg/L, and a comparison of the microbial plate counts of the control, reference substance, test substance and toxicity control solutions at day 28.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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