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Diss Factsheets
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EC number: 214-353-5 | CAS number: 1122-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N,N-dimethylpyridin-4-amine
- EC Number:
- 214-353-5
- EC Name:
- N,N-dimethylpyridin-4-amine
- Cas Number:
- 1122-58-3
- Molecular formula:
- C7H10N2
- IUPAC Name:
- N,N-dimethylpyridin-4-amine
- Test material form:
- solid: crystalline
- Details on test material:
- The test substance was material prepared in a company lab and recrystallized twice from benzene and three times from benzene/hexane into a fine white crystalline material. It had a constant freezing point of 11.6 degrees C, and a purity of 100% by GLC. The boiling point was 162.5 degrees C, solubility in water of 7.6 g at 25 degrees C, and a flash point of 230 degrees F. This is comparable to current commerical product.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 grams
- Fasting period before study: 24 hours during which water was allowed
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water : ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- 10%
- Doses:
- 250, 500, 1000, 2000 and 4000 ml/kg bw of the 10% solution in water, equivalent to 25, 50, 100, 200 and 400 mg/kg bw of test material.
- No. of animals per sex per dose:
- Five males per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily for 14 days
- Necropsy of survivors performed: No
- Other examinations performed: clinical signs, body weight. - Statistics:
- All animals dosed at 250 and 500 mg/kg survived the experiment, while 4 of 5 dosed at 1000 mg/kg survived. At doses over 1000 mg/kg, animals showed increased levels of nervous system depression within 2-3 hrs of dosing.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 140 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 100 - < 200
- Remarks on result:
- other: as 10% solution in water
- Mortality:
- Att 100 mg/kg 1 out of 5 animals died after 1 day. 4 animals survived the 14 day observation period.
At 200 mg/kg, 3 out of 5 animals died after 1 day and 1 animal died on day 2. 1 animal survived 14 days.
At 400 mg/kg dosing all 5 animals died at day 1. - Clinical signs:
- other: From 1000 mg/kg and higher all the animals showed advancing degrees of depression with death occuring as noted above. All the surviving animals were normal at day 7 observation.
- Gross pathology:
- No remarkable pathology
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information LD50 is greater then 50 and less than 300 mg/kg bw. Criteria used for interpretation of results: EU
- Conclusions:
- 4-Dimethylaminopyridine displayed a LD50 of 140 mg/kg in male albino rats in a standard acute oral toxicity assay. As the LD50 is higher than 50 mg/kg bw but less than 300 mg/kg bw, the substance is classified for acute toxicity as Category 3 according to Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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