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Diss Factsheets
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EC number: 217-288-0 | CAS number: 1800-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 6 June 2001 To 3 July 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study without deviation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorodeca-1,9-diene
- EC Number:
- 217-288-0
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorodeca-1,9-diene
- Cas Number:
- 1800-91-5
- Molecular formula:
- C10H6F12
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorodeca-1,9-diene
- Reference substance name:
- 1,6 Divinylperfluorohexane
- IUPAC Name:
- 1,6 Divinylperfluorohexane
- Test material form:
- other: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- AlpK:APfSD (Wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Rodent Breeding Unit, Alderley Park, Macclesfield, Cheshire, UK.
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 335 - 357 g +/-9.1 (males); 239-255 g +/- 6.1 (females)
- Housing: 5 per cage per sexe
- Diet (e.g. ): Diet (RM1), supplied by Special Diet Services Limited, Witham, Essex, UK, ad libitum
- Water (e.g. ad libitum): mains water, supplied by an automatic system, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3 (see also inhalation exposure below for the exposure period)
- Humidity (%): 30 -70 (see also inhalation exposure below for the exposure period)
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12h/ 12h
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The rats were exposed nose-only to the test atmospheres. Animals were restrained in polycarbonate tubes supplied by Battelle, Geneva, Switzerland. These were inserted into a PERSPEX exposure chamber. The chamber was covered with an aluminium cone and stood on an aluminium base.
- Exposure chamber volume: The chamber consisted of sections of PERSPEX tubing (6 mm wall thickness) with an internal diameter of 28 cm and height of 15 cm (approximate volume 9.2 litres).
- System of generating vapour: The test atmosphere was generated using a heated, jacketed glass condenser. The test substance was pumped to the condenser using a Watson Marlow peristaltic pump. A counter current of clean, dry air (dried and filtered using equipment supplied by Atlas-Copco, Sweden) was passed at a nominal flow rate of 20l/minute (at normal temperature and pressure) through the condenser and carried the atmosphere to the exposure chamber (internal volume of 27.6 litres), in order to achieve a minimun of 12 air changes per hour. Since diluting air was not employed, the flow rates through the exposure chambers were the same as that employed in the generation of the test atmosphere. Air flows were monitored continuously and recorded at least 3 times using variable area flowmeters (KDG Flowmeters, Burgess Hill, Sussex, UK)
- Temperature, humidity, pressure in air chamber: The temperature and relative humidity in each chamber were recorded at least 3 times during exposure using a portable, digital temperature and relative humidity monitor; they were within the range of 20.4-21.2 °C and 15-20 % respectively.
TEST ATMOSPHERE
- Brief description of analytical method used: Samples were analysed using gas chromatography.
- Samples taken from breathing zone: yes. Test atmospheres were sampled from a front-facing port of the relevant exposure chamber, using a 5 ml gas-tight syringe equipped with an integral on-off valve and detachable sampling probe. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Target concentration: 1800 ppm (correspond to 26.07 mg/l; MW=354.1355 g/mol) = maximum stable vapour concentration achievable, as determined in a trial generation.
Achieved concentration: 1761 ppm (correspond to 25.5 mg/l; MW= 354.1355 g/mol) - No. of animals per sex per dose:
- 5 per sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:Prior to the start of the study, all rats were examined to ensure that they were physically normal and exhibited normal activity. During exposure, they were observed frequently. At the end of the 4-hour exposure period, each rat was given a detailed clinical examination. The animals were also given detailed clinical observations, (including the finding of "no abnormalities detected') daily during the 14 day observation period.
- Necropsy of survivors performed: yes, all animals were given a gross examination post mortem. This involved an external observation and an internal examination of all thoracic and abdominal viscera.
- Other examinations performed: clinical signs, body weight (d-1, d1, d8, d15) - Statistics:
- No statistics were performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 761 ppm
- Based on:
- test mat.
- Remarks:
- (vapours)
- Exp. duration:
- 4 h
- Remarks on result:
- other: correspond to 25.5 mg/l (maximum stable vapour concentration achievable)
- Mortality:
- There were no deaths in animals exposed to 1761 ppm during the exposure or observation periods.
- Clinical signs:
- other: Observations during exposure: Abnormalities generally associated with restraint (wet fur and chromodacryorrhoea) were seen in some animals exposed to 1761 ppm. All animals had stains around the snout. Observations immediately after exposure: All animals h
- Body weight:
- All animals had gained weight by day 8 of the study and this trend continued until day 15.
- Gross pathology:
- There were no macroscopic changes seen post mortem.
- Other findings:
- None. There was no evidence of respiratory irritation or toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- CLP criteria
- Conclusions:
- Under the experimental conditions of this test, no deaths occurred at a vapour concentration of 1761 ppm (25.5 mg/l; maximum stable vapour concentration achievable) and there was no evidence of respiratory irritation or toxicity.
- Executive summary:
One group of five male and five female Alpk:APfSD (Wistar-derived) rats were exposed nose-only for a single four-hour period to a vapour of dodecafluoro, deca-1,9 -diene at a target concentration of 1800 ppm (which was the maximum stable vapour concentration achievable). Test atmospheres were analysed to determine the vapour concentration of the test substance. Following exposure, the animals were retained without treatment for 14 days. Clinical observations and bodyweights were recorded throughout the study and at the end of the scheduled period, the animals were killed and given a gross examination post mortem. At an exposure concentration of 1761 ppm all animals had gained weight by day 8 and the trend continued throughout the study. There were no clinical changes indicative of toxicity, no macroscopic changes and no deaths. Nose-only exposure for 4 hours to Dodecafluoro, deca-1,9-diene at a vapour concentration of 1761 ppm caused no deaths. Under the test conditions, the acute inhalation LC50 of test material in rats was determined to be higher than 1761 ppm (correspond to 25.5 mg/l, vapours), thus the test substance does not require classification according to CLP Regulation (EC 1272/2008).
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