Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 288-307-8 | CAS number: 85711-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Well documented expert statement based on a series of physicochemical, environmental and toxicology studies with WS400107 in general performed according to technical guidelines and in compliance with GLP in internationally recognized contract research organizations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Expert statement based on a series of physicochemical, environmental and toxicology studies with WS400107. Technical guidelines followed in these experimental studies are cited in the respective endpoint study records.
- GLP compliance:
- no
- Remarks:
- Considered unnecessary for expert statement
Test material
- Test material form:
- liquid: viscous
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: Detailed in endpoint study records of in-vivo studies referred to in the present expert statement
- Strain:
- other: Detailed in endpoint study records of in-vivo studies referred to in the present expert statement
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Detailed in the endpoint study records of in-vivo studies referred to in the present expert statement.
Administration / exposure
- Route of administration:
- other: Detailed in endpoint study records of in-vivo studies referred to in the present expert statement
- Vehicle:
- other: Detailed in endpoint study records of in-vivo studies referred to in the present expert statement, if appropriate
- Details on exposure:
- Detailed in endpoint study records of in-vivo studies referred to in the present expert statement.
- Duration and frequency of treatment / exposure:
- Detailed in endpoint study records referred to in the present expert statement.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Detailed in endpoint study records of in-vivo studies referred to in the present expert statement.
- No. of animals per sex per dose / concentration:
- Detailed in endpoint study records of in-vivo studies referred to in the present expert statement.
- Control animals:
- other: Detailed in endpoint study records referred to in the present expert statement, if applicable
- Positive control reference chemical:
- Detailed in endpoint study records referred to in the present expert statement, if applicable
- Details on study design:
- Detailed in endpoint study records referred to in the present expert statement, if applicable
- Details on dosing and sampling:
- Detailed in endpoint study records referred to in the present expert statement, if applicable
- Statistics:
- Detailed in endpoint study records referred to in the present expert statement, if applicable. Not applicable for the present expert statement.
Results and discussion
- Preliminary studies:
- Not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The test material, WS400107, is a complex mixture of components. The low water solubility (< 1 mg/L at 20°C), high lipophilicity (Log10Pow > 6.2 at 25°C) and, to some extent, the molecular weight (ca. 300 – 800) of WS400107 would be expected to limit its rate of transfer between the stratum corneum and the lower epidermis and dermis after topical administration, and to limit its absorption after oral administration [ECHA 2012, Chapter R.7c: Endpoint specific guidance]. Consequently the above physicochemical properties of WS400107 are considered to limit its systemic availability both, after topical and after oral administration.
However, in view of the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400107, some dermal absorption must have occurred. This may have been only a small fraction of the administered test material.
In addition, absorption of WS400107, or at least a small fraction thereof, after oral gavage administration was concluded from changes in a number of blood plasma parameters indicative of altered hepatic function after five weeks of treatment at 400 or 1000 mg/kg/day in an oral repeat dose toxicity study. In the absence of confirmatory histopathology findings, the changes in blood plasma parameters were not considered to be toxicologically relevant. Dose related adverse effects on bodyweight gain and food consumption were observed in male animals in this study at 400 and 1000 mg/kg/day. Treatment related macroscopic and microscopic pathology findings in the intestines in this study were considered to result from ingestion of the test material by macrophages.
Inhalation exposure to WS400107 is unlikely, because it has a very low vapour pressure (4 x 10E-3 Pa at 25°C) and decomposes without boiling (above ca. 155°C) both limiting its availability under a vapour state, and because it is a highly viscous liquid limiting its availability as an inhalable aerosol. - Details on distribution in tissues:
- There is no indication in the available study results regarding the metabolism or distribution of WS400107 or components thereof.
- Details on excretion:
- There is no indication in the available study results regarding the excretion of WS400107 or components thereof.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Παρόλο που ο Οργανισμός παρέχει μεγάλο μέρος του διαδικτυακού περιεχομένου στη γλώσσα σας, ένα μέρος αυτής της σελίδας είναι μόνο στα αγγλικά. Περαιτέρω πληροφορίες για την πολύγλωσση πρακτική του ECHA.
Καλώς ήρθατε στον δικτυακό τόπο του ECHA. Η παρούσα ιστοθέση δεν υποστηρίζεται πλήρως από τον Internet Explorer 7 (ή προγενέστερες εκδόσεις). Αναβαθμίστε τον φυλλομετρητή σας Internet Explorer σε πιο πρόσφατη έκδοση.
Ο παρών ιστότοπος χρησιμοποιεί cookies για να διασφαλίζεται ότι αποκομίζετε την καλύτερη δυνατή εμπειρία από την περιήγησή σας στους ιστοτόπους μας.
Μάθετε περισσότερα σχετικά με τον τρόπο που χρησιμοποιούμε τα cookies.