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EC number: 413-370-7 | CAS number: 17351-75-6 RAPICURE CHVE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only study summary availiable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- J.H. Draize, "Dermal Toxicity", Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, (The Association of Food and Drug Officials of the United States, (1975), pp. 52 - 54.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,4-bis[(vinyloxy)methyl]cyclohexane
- EC Number:
- 413-370-7
- EC Name:
- 1,4-bis[(vinyloxy)methyl]cyclohexane
- Cas Number:
- 17351-75-6
- Molecular formula:
- C12 H20 O2
- IUPAC Name:
- (1r,4r)-1,4-bis[(ethenyloxy)methyl]cyclohexane; (1s,4s)-1,4-bis[(ethenyloxy)methyl]cyclohexane
- Details on test material:
- - Name of test material (as cited in study report): Divinyl ether of 1,4-cyclohexane, dimethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: CAMM Research (Wayne, NJ, USA)
- Age at study initiation: approx. 3 month
- Weight at study initiation: approx. 2 kg
- Housing: single
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 3 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.3 - 23,9 °C (65 - 75 ° F)
- Photoperiod (hrs dark / hrs light): 12 h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- The eyes of six (6) animals remained unwashed for 24 hours; the eyes of the remaining three (3) animals were washed out 30 seconds after instillation of the test article.
- Observation period (in vivo):
- Observations of corneal opacity, iritis, conjunctivitis, and other effects were recorded 24, 48, and 72 hours after treatment, and at day 4.
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 30 Minutes after start of exposure 3 rabbits and 24 h after start of exposure 6 rabbits.
SCORING SYSTEM:
Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 - 72
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: only unwashed eyes data
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: only unwashed eyes data
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: only unwashed eyes data
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 - 72
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: only unwashed eyes data; reverible within 4 days
- Irritant / corrosive response data:
- Only minimal irritation effects were observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
The study is a guideline study according to US cosmetics regulation. However, the study is reliable with restriction because there is only a summary availiable which provides poor information concerning the test substance identity.
Nine New Zealand white rabbits, free from visible ocular defects, each received a cingle intraocular application of 0.1 milliliter of the test article. The contralateral eye, remaining untreated, served as a control. The eyes of six animals remained unwashed for 24 hours; the eyes of the remaining three animals were washed out 30 seconds after instillation of the test article. Observations of corneal opacity, iritis, conjunctivitis, and other effects were recorded 24, 48, and 72 hours after treatment, and at day 4.
The instillation of 1,4 dimethylol-divinylether cyclohexane resulted in a slight erythema (mean 0.2), but no other effect was observed for the unwashed eye. Therefore 1,4 dimethylol-divinylether cyclohexane was considered not irritating to the eyes (score 0.3 of max 110) .
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