Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-057-8 | CAS number: 554-00-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- nephrotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute nephrotoxicity induced by isomeric dichloroanilines in Fischer 344 rats
- Author:
- Lo HH, Brown PI, and Rankin GO
- Year:
- 1 990
- Bibliographic source:
- Toxicology 63: 215-231
- Reference Type:
- publication
- Title:
- Acute nephrotoxicity induced by chlorinated anilines
- Author:
- Lo HHS
- Year:
- 1 989
- Bibliographic source:
- Dissertetion. West Virginia University
Materials and methods
- Principles of method if other than guideline:
- The nephrotoxic potential of 2,4-dichloroaniline isomers was examined. Male rats were administered a single, intraperitoneal injection of 2,4-dichloroaniline as the hydrochlorid salt or given vehicle (0.9% saline), and renal function monitored at 24 and 48 hours.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2,4-dichloroaniline
- EC Number:
- 209-057-8
- EC Name:
- 2,4-dichloroaniline
- Cas Number:
- 554-00-7
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,4-dichloroaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- no
- Frequency of treatment:
- once
- Post exposure period:
- 24 or 48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.4, 0.8, or 1.0 mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- from minimal of 4 rat to maximum of 8 rats
- Control animals:
- no
Results and discussion
- Details on results:
- Three of eight animals died in the 2,4-DCA (0.8 mmol/kg) treatment group.
Any other information on results incl. tables
BUN concentration was increased on day 2 following administration of 2,4 -dichloroaniline. TEA uptake was not reduced in any treatment group but was increased in the 2,4 -dichloroaniline (0.4 or 0.8 mmol/kg)
In vitro effects of dichloroanilines isomers
The overall in vitro effects of the dichloroanilines isomers on organic ion accumulation were similar. All compounds decreased lactate-stimulated PAH and TEA accumulation at a bath concentration of 10 -3 M. None of the compunds were able to inhibit TEA or lactate-stimulated PAH accumulation at concentration of 10-5M or less
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.