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Diss Factsheets
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EC number: 207-622-3 | CAS number: 485-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity of the read across substance cinchonidine hydrochloride to invertebrates:
the read-across substance cinchonidine hydrochloride was tested in astatic Daphnia magna, Acute Immobilisation Test according to the OECD Guideline 202 for 48 h. Five nominal concentrations between 26 and 100 mg/L were used. The EC50 of cinchonidine hydrochloride is 68.09 mg/L for Daphnia magna during the test period of 48 h. According to this, the EC50 of cinchonidine is 60.5 mg/L.
Short-term toxicity of the read across substance quinine to green algae:
In publication of Moreno-Garrido, 2001 the toxicity of the read across substance quinine sulphate to green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L. We conclude that cinchonidine which differs in a methoxy group has a similar EC50 value.
Toxicity of cinchonidine to aquatic plants:
In the publication of Wink, 1992 the toxicity of cinchonidine to Lemna gibba was determined for 6 days. At a concentration of 0.4% cinchonidine lead to death. Bleaching of Lemna gibba was observed at a concentration of 0.04%.
Toxicity of cinchonidine to microorganisms:
In the study published by Wink, 1998 the bacterial growth inhibition of Bacillus subtilis, Escherichia coli and Serratia marcescens was determined. The IC100 of cinchonidine for E. coli is 3 mM (883.2 mg/L) and the IC100 for B. subtilis and S. marcescens is 10 mM (2.94 g/L). Cinchonidine has an antibacterial activity.
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